Results 51 to 60 of about 857,471 (304)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Immunizing Mice with Influenza Virus-like Particles Expressing the Leishmania amazonensis Promastigote Surface Antigen Alleviates Inflammation in Footpad

Vaccines
Cutaneous leishmaniasis (CL) is a tropical disease endemic in many parts of the world. Characteristic clinical manifestations of CL include the formation of ulcerative skin lesions that can inflict life-long disability if left untreated.
Gi-Deok Eom, Ki Back Chu, Keon-Woong Yoon, Jie Mao, Sung Soo Kim, Fu-Shi Quan   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reactive oxygen species and redox signaling in breast cancer

, 2017
Breast cancer progression depends on host innate and adaptive immune responses. Despite the effect of immune system in tumor destruction, cancer cells may induce the immune cells to support tumor progression.
Silva, Mateus Batista [UNESP], Panis, Carolina, De Andrade, Ana Carolina, Victorino, Vanessa Jacob, Pires, Bruno Ricardo Barreto   +4 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reactive Oxygen Species and Male Fertility

Antioxidants, 2020
Human infertility affects ~15% of couples worldwide, and it is now recognized that in half of these cases, the causes of infertility can be traced to men [...]
Cristian O’Flaherty
doaj   +1 more source

Plasma reactive oxygen species levels are correlated with severity of age-related hearing impairment in humans

, 2014
To investigate the relationship between plasma reactive oxygen species (ROS) levels and severity of age-related hearing impairment in humans. We recruited 302 adult subjects aged 40-77 years with normal or symmetrical sensorineural hearing loss.
許權振 ;劉殿楨 ;楊偉勛, Hwang, Juen-Haur;Chen, Jin-Cherng;Hsu, Chuan-Jen;Yang, Wei-Shiung;Liu, Tien-Chen   +1 more
core   +1 more source

Assessing the protection elicited by virus-like particles expressing the RSV pre-fusion F and tandem repeated G proteins against RSV rA2 line19F infection in mice

Respiratory Research
Excessive pulmonary inflammation is the hallmark of respiratory syncytial virus (RSV) infection hindering efficacious RSV vaccine development. Yet, the vast majority of the experimental RSV vaccine studies use laboratory-adapted RSV strains that do not ...
Min-Ju Kim, Ki Back Chu, Su-Hwa Lee, Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Eun-Kyung Moon, Fu-Shi Quan   +7 more
doaj   +1 more source

Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection

Emerging Microbes and Infections
Influenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes.
Jie Mao, Ki Back Chu, Gi-Deok Eom, Keon-Woong Yoon, Su In Heo, Hae-Ji Kang, Sung Soo Kim, Fu-Shi Quan   +7 more
doaj   +1 more source