Results 61 to 70 of about 857,471 (304)

Reactive oxygen species and redox compartmentalization

Frontiers in Physiology, 2014
Reactive oxygen species (ROS) formation and signaling are of major importance and regulate a number of processes in physiological conditions. A disruption in redox status regulation, however, has been associated with numerous pathological conditions.
Nina eKaludercic, Soni eDeshwal, Fabio eDi Lisa, Fabio eDi Lisa   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Serum reactive oxygen species and apoptosis markers in septic patients [PDF]

, 2020
Background: Oxidative stress is one of the pathophysiological processes that occur during sepsis. Reactive oxygen species (ROS) production causes lipid peroxidation and protein and DNA damage. ROS and DNA damage triggers apoptosis.
Isabel Burgos, Manuel Alonso, Chapela, Sebastián Pablo, Schiel, Amalia, Sebastián Pablo Chapela, Burgos, Hilda Isabel, Amalia Schiel, Stella, Carlos Alberto, Carlos Alberto Stella, Alonso, Manuel   +9 more
core   +1 more source

Senescence, Stress, and Reactive Oxygen Species

Plants, 2015
Generation of reactive oxygen species (ROS) is one of the earliest responses of plant cells to various biotic and abiotic stresses. ROS are capable of inducing cellular damage by oxidation of proteins, inactivation of enzymes, alterations in the gene ...
Ivan Jajic, Tadeusz Sarna, Kazimierz Strzalka   +2 more
doaj   +1 more source

Generation of Reactive Oxygen Species from Silicon Nanowires

Environmental Health Insights, 2014
Processing and synthesis of purified nanomaterials of diverse composition, size, and properties is an evolving process. Studies have demonstrated that some nanomaterials have potential toxic effects and have led to toxicity research focusing on ...
Stephen S. Leonard, Guy M. Cohen, Allison J. Kenyon, Diane Schwegler-Berry, Natalie R. Fix, Sarunya Bangsaruntip, Jenny R. Roberts   +6 more
doaj   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Elicitor effects on reactive oxygen species in liquid cultures of Penicillium chrysogenum

, 2004
Activity of reactive oxygen species (ROS) was investigated in liquid cultures of Penicillium chrysogenum P2 supplemented with carbohydrates. Oligosaccharides lowered the ROS activity in all samples. The greatest effect occurred when oligosaccharides were
Keshavarz, T., Bucke, C., Radman, R.
core   +1 more source

Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats [PDF]

, 2010
Background: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced during hemorrhagic shock and resuscitation (H/R), which may contribute to multiple organ failure.
Zhong, Zhi, Lehnert, Mark, Schoonhoven, Robert, Marzi, Ingo, Zhi Zhong, Lind, Henrik, Lemasters, John J., Schoonhoven Robert, Lemasters John J, Lehnert Mark, Ingo Marzi, Marzi Ingo, Henrik Lind, Robert Schoonhoven, Zhong Zhi, Lind Henrik, Mark Lehnert, John J Lemasters   +17 more
core   +1 more source

Inhaled microcystin-LR may induce acute liver failure through hepatic congestion

Ecotoxicology and Environmental Safety
As cyanobacteria growth increases due to climate change, health issues resulting from exposure to microcystin-leucine-arginine (MC-LR), a toxin produced by cyanobacteria, are becoming a pressing public health concern.
Wonkyun Jung, Mi-Jin Yang, Su-Hyeon Jo, Ji Ae Lee, Nam Chul Kwon, Seong-Jin Choi, Hyosun Choi, Cheon Woong Choi, Moonhyung Lee, Jin-Bae Kim, Eun-Jung Park   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source