Results 61 to 70 of about 1,231,759 (345)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Immunizing Mice with Influenza Virus-like Particles Expressing the Leishmania amazonensis Promastigote Surface Antigen Alleviates Inflammation in Footpad

Vaccines
Cutaneous leishmaniasis (CL) is a tropical disease endemic in many parts of the world. Characteristic clinical manifestations of CL include the formation of ulcerative skin lesions that can inflict life-long disability if left untreated.
Gi-Deok Eom, Ki Back Chu, Keon-Woong Yoon, Jie Mao, Sung Soo Kim, Fu-Shi Quan   +5 more
doaj   +1 more source

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy. [PDF]

, 2016
Mitochondrial reactive oxygen species production has emerged as an important pathological mechanism in myocardial ischemia/reperfusion injury. Attempts at targeting reactive oxygen species by scavenging using antioxidants have, however, been clinically ...
Brookes, Paul S, Chouchani, Edward T, Krieg, Thomas, Murphy, Michael P, Pell, Victoria R   +4 more
core   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Assessing the protection elicited by virus-like particles expressing the RSV pre-fusion F and tandem repeated G proteins against RSV rA2 line19F infection in mice

Respiratory Research
Excessive pulmonary inflammation is the hallmark of respiratory syncytial virus (RSV) infection hindering efficacious RSV vaccine development. Yet, the vast majority of the experimental RSV vaccine studies use laboratory-adapted RSV strains that do not ...
Min-Ju Kim, Ki Back Chu, Su-Hwa Lee, Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Eun-Kyung Moon, Fu-Shi Quan   +7 more
doaj   +1 more source

Identification of differentially expressed Legionella genes during its intracellular growth in Acanthamoeba

Heliyon, 2020
Legionella grows intracellularly in free-living amoeba as well as in mammalian macrophages. Until now, the overall gene expression pattern of intracellular Legionella in Acanthamoeba was not fully explained. Intracellular bacteria are capable of not only
Fu-Shi Quan, Hyun-Hee Kong, Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon   +4 more
doaj  

Antimicrobial Actions of Reactive Oxygen Species

mBio, 2011
Everything should be as simple as it can be, but not simpler.—Attributed to Albert Einstein (1) IMPORTANCE Reactive oxygen species (ROS) are produced by host phagocytes and exert antimicrobial actions against a broad range of pathogens.
Ferric C. Fang
doaj   +1 more source

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection

Emerging Microbes and Infections
Influenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes.
Jie Mao, Ki Back Chu, Gi-Deok Eom, Keon-Woong Yoon, Su In Heo, Hae-Ji Kang, Sung Soo Kim, Fu-Shi Quan   +7 more
doaj   +1 more source