Results 61 to 70 of about 712,690 (299)

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]

, 2014
Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed, Liu, Zhiping, Lupfer, Christopher R, Stokes, Kate L, Vogel, Peter   +6 more
core   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A review of redox signaling and the control of MAP kinase pathway in plants

Redox Biology, 2017
Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved modules among eukaryotic species that range from yeast, plants, flies to mammals.
Yukun Liu, Chengzhong He
doaj   +1 more source

Review: Nanomaterials for Reactive Oxygen Species Detection and Monitoring in Biological Environments

Frontiers in Chemistry, 2021
Reactive oxygen species (ROS) and dissolved oxygen play key roles across many biological processes, and fluorescent stains and dyes are the primary tools used to quantify these species in vitro.
Gabriel T. Huynh, Gabriel T. Huynh, Vidhishri Kesarwani, Vidhishri Kesarwani, Julia A. Walker, Julia A. Walker, Jessica E. Frith, Jessica E. Frith, Jessica E. Frith, Laurence Meagher, Laurence Meagher, Simon R. Corrie, Simon R. Corrie, Simon R. Corrie   +13 more
doaj   +1 more source

Reactive Oxygen Species (ROS) Responsive Polymers for Biomedical Applications [PDF]

Macromolecular Bioscience, 2016
Reactive oxygen species (ROS) play important roles in cell signaling pathways, while increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress and a series of diseases. Utilizing these cell‐generated species as triggers for selective tuning polymer structures and properties represents a promising methodology for ...
Qinghua, Xu, Chaoliang, He, Chunsheng, Xiao, Xuesi, Chen   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Reactive oxygen species (ROS): sources, generation, disease pathophysiology, and antioxidants

Discover Chemistry
Reactive oxygen species (ROS) are widely known as highly reactive signalling and transcription factors. They have shown beneficial effects at low concentrations to regulate multiple cellular processes like proliferation, differentiation, migration ...
Waseem Ahmad Ansari, Kajal Srivastava, Malik Nasibullah, Mohammad Faheem Khan   +3 more
doaj   +1 more source

Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy including senscence, necrosis, and autophagy, but not apoptosis [PDF]

, 2015
In comparison to more differentiated cells, prostate cancer stem-like cells are radioresistant, which could explain radio-recurrent prostate cancer. Improvement of radiotherapeutic efficacy may therefore require combination therapy.
Boyle, Ross W., Bryden, Francesca, Frame, Fiona M., Giuntini, Francesca, Maitland, Norman J., Mann, Vincent M., Savoie, Huguette, Simms, Matthew S.   +7 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Reducing pesticide use: Synthesis and application of ROS-SPC as an efficient nanocarrier and scavenger of reactive oxygen species in plants

Advanced Agrochem
There is an increasing need to reduce the use of pesticides to reduce their potential threat to food/environmental safety. At the same time, an increase in reactive oxygen species (ROS) induced by abiotic stresses in plants can lead to an increase in ROS
Tian-shi Jiang, Su-zhen Qi, Chang-heng Zhu, Han-qing Zhao, Liu-sheng Duan   +4 more
doaj   +1 more source