Results 61 to 70 of about 261,656 (264)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

Reactive power regulation strategy for WTGs based on active disturbance rejection control

open access: yesFrontiers in Energy Research
With the large-scale interconnection of wind power generation, the voltage problem of the power system becomes more and more prominent. Compared with adding external reactive power compensation devices, it is more economical and responsive for fans to ...
Shuilian Xue   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

An Improved Droop Control Strategy for Low-Voltage Microgrids Based on Distributed Secondary Power Optimization Control

open access: yesEnergies, 2017
To achieve accurate reactive power sharing and voltage frequency and amplitude restoration in low-voltage microgrids, a control strategy combining an improved droop control with distributed secondary power optimization control is proposed. The active and
Demin Li   +4 more
doaj   +1 more source

Distributed control algorithm for optimal reactive power control in power grids

open access: yesInternational Journal of Electrical Power & Energy Systems, 2016
Abstract Reactive power generation has been commonly used for power loss minimization and voltage profile improvement in power systems. However, the opportunity cost of reactive power generation should be considered since it affects the frequency control capability of the generator to some degree.
Irfan Khan   +3 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Optimal reactive power control in a converter station during low-power operation of HVDC

open access: yesThe Journal of Engineering, 2019
When the high-voltage DC (HVDC) system is operated in low-power transmission, the overplus of reactive power provided by AC filters may still exist apart from satisfying the need of the converter station, restricted by the minimum number of filter banks.
Jingshan Mo   +5 more
doaj   +1 more source

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