Results 51 to 60 of about 59,403 (217)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Bioenergetics and Reactive Nitrogen Species in Bacteria
International Journal of Molecular Sciences, 2022 The production of reactive nitrogen species (RNS) by the innate immune system is part of the host’s defense against invading pathogenic bacteria. In this review, we summarize recent studies on the molecular basis of the effects of nitric oxide and peroxynitrite on microbial respiration and energy conservation.
Vitaliy B. Borisov, Elena Forte
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Influenza A hemagglutinin virus-like particles confer protection against influenza B virus infection
Emerging Microbes and InfectionsInfluenza A hemagglutinin (HA), neuraminidase, and/or M2e-containing virus-like particles (VLPs) induce immune responses that contribute to protection against multiple influenza A virus subtypes.
Jie Mao +7 more
doaj +1 more source
Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells
Applied Sciences, 2019 Recent advances in melanoma therapy increased median survival in patients. However, death rates are still high, motivating the need of novel avenues in melanoma treatment.
Katrin Rödder +6 more
doaj +1 more source
Clinical Characteristics and Short-term Outcomes of Acute Low Frequency Sensorineural Hearing Loss With Vertigo [PDF]
Clinical and Experimental Otorhinolaryngology, 2018 Objectives This study analyzed short-term prognosis in patients with acute low frequency hearing loss (ALHL), and also investigate hearing recovery rates in patients with ALHL accompanied vertigo.
Myung Jin Park +3 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
International Journal of Smart and Nano Materials, 2019 Cold atmospheric plasmas are currently gaining increasing attention for cancer therapy. However, very limited studies regarding the interaction mechanisms between plasma species and tissues are available.
Rong-Guang Xu +3 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Inhaled microcystin-LR may induce acute liver failure through hepatic congestion
Ecotoxicology and Environmental SafetyAs cyanobacteria growth increases due to climate change, health issues resulting from exposure to microcystin-leucine-arginine (MC-LR), a toxin produced by cyanobacteria, are becoming a pressing public health concern.
Wonkyun Jung +10 more
doaj +1 more source