Results 71 to 80 of about 4,838,205 (202)

Inter-Tools: a toolkit for interactome analysis

, 2017
Interactome analysis is an increasingly useful tool for discovering disease pathways. However, protein interaction data is scattered among different sources, and researchers must often sift through several large repositories before beginning a project ...
Jose Ordovas, Hannah Beth Catabia, Caren Smith   +2 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation. [PDF]

Mol Ecol
ABSTRACT Gene Ontology (GO) enrichment analysis has been widely adopted for interpretating omics data, including in ecological research. Although valuable for summarizing large gene lists into functional categories, it is often treated as the final interpretive step.
Ahi EP, Karagic N, Papakostas S.
europepmc   +2 more sources

MiGiNull/Ece1p-interactome: v1.0

<p>Network and Functional Analysis of Ece1p-Human Interactome for Novel Target Identification</p ...
MiGiNull
core   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases

Microbiome
Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies.
Alejandro Artacho, Cintya González-Torres, Nuria Gómez-Cebrián, Paula Moles-Poveda, Javier Pons, Nuria Jiménez, María Jinglei Casanova, Juan Montoro, Aitana Balaguer, Marta Villalba, Pedro Chorão, Leonor Puchades-Carrasco, Jaime Sanz, Carles Ubeda   +13 more
doaj   +1 more source

Integrated transcriptomic and metabolomic profiling reveals coordinated regulatory networks associated with mosaic disease resistance in sugarcane

Frontiers in Plant Science
IntroductionSugarcane mosaic disease (SCMD) poses a severe threat to global sugarcane yield. Since conventional field management is insufficient to restrict viral transmission, unraveling the underlying defense mechanisms is imperative for targeted ...
Mingjie You, Mingjie You, Hui Li, Hui Li, Yan Xie, Yan Xie, Ze Liu, Ze Liu, Xuelu Wei, Xuelu Wei, Jiahe Wu, Jiahe Wu, Yi Xu, Qing Zhang, Qing Zhang, Jisen Zhang, Jisen Zhang, Qiutao Xu, Qiutao Xu, Heyang Shang, Heyang Shang   +20 more
doaj   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

The protective role of vitamin C in diabetic retinopathy and TPT1 as a potential therapeutic target

Nutrition & Metabolism
Background Diabetic retinopathy (DR), the primary driver of preventable vision impairment in the global working-age demographic, arises from chronic hyperglycaemia and manifests as non-proliferative or proliferative retinopathy with or without diabetic ...
Yuanyuan Zhang, Jiaxin Li, Xiaorong Li, Yan Shao   +3 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source