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The Path to Controlled Delivery of Reactive Sulfur Species
Accounts of Chemical Research, 2021Reactive sulfur species (RSS) play regulatory roles in many physiological and pathological processes. Since the discovery of hydrogen sulfide (H2S) as a nitric oxide (NO)-like signaling molecule, understanding the chemical biology of H2S and H2S-related RSS, such as hydropersulfides (RSSH) and polysulfides (H2Sn), has become a fast-growing research ...
Xiang Ni +3 more
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Hydrogen sulfide, reactive sulfur species and coping with reactive oxygen species
Free Radical Biology and Medicine, 2019Life began in a ferruginous (anoxic and Fe2+ dominated) world around 3.8 billion years ago (bya). Hydrogen sulfide (H2S) and other sulfur molecules from hydrothermal vents and other fissures provided many key necessities for life's origin including catalytic platforms (primordial enzymes) that also served as primitive boundaries (cell walls ...
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Reactive Sulfur Species: Aqueous Chemistry of Sulfenyl Thiocyanates
Journal of the American Chemical Society, 2004Sulfenyl thiocyanate (RSSCN) derivatives of penicillamine (PENSCN) and glutathione (GSSCN) have been synthesized in situ at pH = 0 from equilibrium mixtures that consists of hypothiocyanous acid (HOSCN), thiocyanogen ((SCN)2), and trithiocyanate ((SCN)3-). The electrophilic thiocyanating agent N-thiocyanatosuccinimide (NTS) also reacts with PEN and GSH
Michael T, Ashby, Halikhedkar, Aneetha
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Reactive sulfur species (RSS): persulfides, polysulfides, potential, and problems
Current Opinion in Chemical Biology, 2019Sulfur is a crucial element in biology due to its unique properties and wide range of accessible oxidation states. This reactivity gives rise to the generation of reactive sulfur species (RSS), which have emerged as a diverse class of small molecules and functional groups with important roles in chemical biology and bioinorganic chemistry.
Nathanael, Lau, Michael D, Pluth
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Journal of the American Chemical Society, 2022
A zinc dithiolate complex supported by a [N3S2] ligand was studied as a model for zinc-mediated thiolate-disulfide exchange, enabling isolation of a zinc-bound mixed-disulfide intermediate. Solution-phase characterization of this zinc-disulfide complex indicates an interaction between the zinc center and the disulfide moiety that results in activation ...
W.T. Michael Seo +2 more
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A zinc dithiolate complex supported by a [N3S2] ligand was studied as a model for zinc-mediated thiolate-disulfide exchange, enabling isolation of a zinc-bound mixed-disulfide intermediate. Solution-phase characterization of this zinc-disulfide complex indicates an interaction between the zinc center and the disulfide moiety that results in activation ...
W.T. Michael Seo +2 more
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Reactive Sulfur Species: An Emerging Concept in Oxidative Stress
Biological Chemistry, 2002The ingredients of oxidative stress include a variety of reactive species such as reactive oxygen and reactive nitrogen species (ROS, RNS). While sulfur is usually considered as part of cellular antioxidant systems there is mounting evidence that reactive sulfur species (RSS) with stressor properties similar to the ones found in ROS are formed under ...
Gregory I, Giles, Claus, Jacob
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Imaging of Intracellular Reactive Nitrogen Species and Reactive Sulfur Species
2020This chapter summarizes representative small-molecule fluorescent probes for reactive nitrogen species and reactive sulfur species in living cells. The design and response mechanisms of the probes are described in detail. Probes that have not been applied in living cell analysis are not included.
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Reactive sulfur and selenium species in the regulation of bone homeostasis
Free Radical Biology and Medicine, 2022Reactive oxygen species (ROS) are important modulators of physiological signaling and play important roles in bone tissue regulation. Both reactive sulfur species (RSS) and reactive selenium species (RSeS) are involved in ROS signaling, and recent work suggests RSS and RSeS involvement in the regulation of bone homeostasis. For example, RSS can promote
Annie K, Gilbert +3 more
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Aconitases: Non-redox Iron–Sulfur Proteins Sensitive to Reactive Species
Accounts of Chemical Research, 2019Mammalian aconitases (mitochondrial and cytosolic isoenzymes) are unique iron-sulfur cluster-containing proteins in which the metallic center participates in the catalysis of a non-redox reaction. Within the cubane iron-sulfur cluster of aconitases only three of the four iron ions have cysteine thiolate ligands; the fourth iron ion (Feα) is solvent ...
Laura Castro +3 more
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Hypothesis: the role of reactive sulfur species in oxidative stress
Free Radical Biology and Medicine, 2001Oxidative stress arises from an imbalance in the metabolism of redox-active species promoting the formation of oxidizing agents. At present, these species are thought to include reactive oxygen, reactive nitrogen, and reactive nitrogen oxygen species (ROS, RNS, and RNOS, respectively).
G I, Giles, K M, Tasker, C, Jacob
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