Results 41 to 50 of about 64,410 (223)
Antioxidants, 2023 Podophyllotoxin (PTOX) is naturally produced by the plant Podophyllum species. Some of its derivatives are anticancer drugs, which are produced mainly by using chemical semi-synthesis methods.
Honglei Liu +10 more
doaj +1 more source
Redox signaling regulated by electrophiles and reactive sulfur species. [PDF]
J Clin Biochem Nutr, 2016 Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. Current redox biology is revisiting the traditional concept of oxidative stress, such that toxic effects of reactive oxygen species are protected by diverse antioxidant systems upregulated by oxidative ...
Nishida M +5 more
europepmc +4 more sources
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species
Cell Reports, 2022 Summary: Gut microbiota act beyond the gastrointestinal tract to regulate the physiology of the host. However, their contribution to the antioxidant capacity of the host remains largely understudied.
Jun Uchiyama +4 more
doaj +1 more source
Reaction Mechanisms of H2S Oxidation by Naphthoquinones
Antioxidants1,4-naphthoquinones (NQs) catalytically oxidize H2S to per- and polysufides and sulfoxides, reduce oxygen to superoxide and hydrogen peroxide, and can form NQ-SH adducts through Michael addition.
Kenneth R. Olson +16 more
doaj +1 more source
Reactive Species-Activatable AIEgens for Biomedical Applications
Biosensors, 2022 Precision medicine requires highly sensitive and specific diagnostic strategies with high spatiotemporal resolution. Accurate detection and monitoring of endogenously generated biomarkers at the very early disease stage is of extensive importance for ...
Xiaoying Kang +4 more
doaj +1 more source
Rhodanese Rdl2 produces reactive sulfur species to protect mitochondria from reactive oxygen species
Free Radical Biology and Medicine, 2021 Mitochondria damage is related to a broad spectrum of pathologies including Alzheimer's, Parkinson's disease, and carcinogenesis. Recently, it has been found that reactive sulfur species (RSS) has a close connection with mitochondrial health.
Qingda Wang +6 more
openaire +2 more sources
Redox Biology, 2017 Catalase is well-known as an antioxidant dismutating H2O2 to O2 and H2O. However, catalases evolved when metabolism was largely sulfur-based, long before O2 and reactive oxygen species (ROS) became abundant, suggesting catalase metabolizes reactive ...
Kenneth R. Olson +6 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Metabolic reprogramming is a cancer hallmark. Although the reprogramming of central carbon has been well documented, the role of sulfur metabolism has been largely overlooked.
Ximing Zhang +7 more
doaj +1 more source
The Reactive Species Interactome in Red Blood Cells: Oxidants, Antioxidants, and Molecular Targets
Antioxidants, 2023 Beyond their established role as oxygen carriers, red blood cells have recently been found to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant cells. Emerging evidence indicates that reactive species derived from
Miriam M. Cortese-Krott
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source