Results 1 to 10 of about 6,704 (99)

The Reactive Species Interactome in Red Blood Cells: Oxidants, Antioxidants, and Molecular Targets [PDF]

Antioxidants, 2023
Beyond their established role as oxygen carriers, red blood cells have recently been found to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant cells. Emerging evidence indicates that reactive species derived from
Miriam M. Cortese-Krott
doaj   +4 more sources

Involvement of endolysosome iron in HIV-1 gp120-, morphine-, and iron supplementation-induced disruption of the reactive species interactome and induction of neurotoxicity [PDF]

Redox Report
Background: Iron continues to be linked to the pathogenesis of neurodegenerative disorders including HIV-1 associated neurocognitive disorders (HAND). People with HIV-1 who use opioids have a higher risk of developing HAND, and HIV-1 proteins and opioids
Nirmal Kumar, Peter W. Halcrow, Darius N. K. Quansah, Braelyn Liang, Olimpia Meucci, Jonathan D. Geiger   +5 more
doaj   +4 more sources

HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors [PDF]

Redox Report
Background Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND).
Nirmal Kumar, Braelyn Liang, Jonathan D. Geiger   +2 more
doaj   +2 more sources

Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner

Neurobiology of Disease
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology.
Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga   +9 more
doaj   +3 more sources

Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia. [PDF]

Int J Mol Sci, 2019
Bos M, Schoots MH, Fernandez BO, Mikus-Lelinska M, Lau LC, Eikmans M, van Goor H, Gordijn SJ, Pasch A, Feelisch M, van der Hoorn MP.   +10 more
europepmc   +2 more sources

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. [PDF]

Antioxid Redox Signal, 2017
Cortese-Krott MM, Koning A, Kuhnle GGC, Nagy P, Bianco CL, Pasch A, Wink DA, Fukuto JM, Jackson AA, van Goor H, Olson KR, Feelisch M.   +11 more
europepmc   +2 more sources

Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter

Antioxidants, 2022
Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory,
Jianyun Liu, Fikir M. Mesfin, Chelsea E. Hunter, Kenneth R. Olson, W. Christopher Shelley, John P. Brokaw, Krishna Manohar, Troy A. Markel   +7 more
doaj   +1 more source

Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma

Antioxidants, 2021
Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear.
Anna Freeman, Doriana Cellura, Magdalena Minnion, Bernadette O. Fernandez, Cosma Mirella Spalluto, Denny Levett, Andrew Bates, Timothy Wallis, Alastair Watson, Sandy Jack, Karl J. Staples, Michael P. W. Grocott, Martin Feelisch, Tom M. A. Wilkinson   +13 more
doaj   +1 more source

Systems redox biology in health and disease

EXCLI Journal : Experimental and Clinical Sciences, 2022
Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges.
Martin Feelisch, Miriam M. Cortese-Krott, Jérôme Santolini, Stephen A. Wootton, Alan A. Jackson   +4 more
doaj   +1 more source

Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Medicina, 2023
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity.
Melvin R. Hayden
doaj   +1 more source