Results 31 to 40 of about 4,838,205 (202)

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Interactome-guided topographic maps of cancer chaperome shifts.

, 2018
A. Cancer-specific chaperome meta-interactome networks, collapsing network nodes and edges onto meta-nodes and meta-edges, highlight cancer-specific gene expression changes of chaperome functional families in context of connectivity within the high ...
Ali Hadizadeh Esfahani (4731474), Andreas A. Schuppert (4731480), Angelina Sverchkova (4731471), Julio Saez-Rodriguez (25229), Marc Brehme (4731477)   +4 more
core   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

interactome

, 2019
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs).
Boqiang Qin, Hambright, K. David, Delphine Latour, Paerl, Hans W, Hamilton, David P, Cai, Haiyuan, Padisak, Judit, Hambright, K David, Krumholz, Lee R., Steffen, Morgan M., Cook, Katherine, Qin, Boqiang, K. David Hambright, Katherine V. Cook, Assaf Sukenik, Morgan M. Steffen, Judit Padisák, Zhu, Guangwei, Meyer, Elisabeth I, Michele A. Burford, David P. Hamilton, Hans‐Peter Grossart, Jiang, Helong, Hamilton, David P., Latour, Delphine, Richard M. Zamor, Guangwei Zhu, Li, Chuang, Elisabeth I. Meyer, Haiyuan Cai, Paerl, Hans W., Burford, Michele A, Hans W. Paerl, Helong Jiang, Zamor, Richard M, Grossart, Hans-Peter, Meyer, Elisabeth I., Meyer, Elisabeth, Grossart, Hans-Peter (Prof. Dr.), Cook, Katherine V., Alan E. Wilson, Wilson, Alan E., Sukenik, Assaf, Lee R. Krumholz, Chuang Li, Cook, Katherine V, Burford, Michele A., Steffen, Morgan M, Wilson, Alan E, Zamor, Richard M., Krumholz, Lee R   +50 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species [PDF]

, 2005
Includes bibliographical references (leaves 73-89).Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects.
Lacerda, Lydia
core   +1 more source

Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) represses sulfide:quinone oxidoreductase expression and targets the sulfido-redox system in glioblastoma models

Redox Report
Background: The adaptation of the redox system and bioenergetics is a major factor contributing to cancer metabolism. Redox therapy is promising but still requires molecular studies that consider the reactive species interactome (RSI) concept, which ...
Elise Malard, Benoît Bernay, Jérôme Toutain, Samantha Ballesta, Marie Lévêque, Julien Pontin, Samuel Valable, Myriam Bernaudin, Laurent Chatre   +8 more
doaj   +1 more source

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Molecular Systems Biology, 2010
Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism.
João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki   +13 more
doaj   +1 more source

Excessive reactive oxygen species induce transcription-dependent replication stress. [PDF]

, 2023
Elevated levels of reactive oxygen species (ROS) reduce replication fork velocity by causing dissociation of the TIMELESS-TIPIN complex from the replisome.
Boleslavska, Barbora, Menon, Shruti, Janscak, P., Andrs, Martin, Surendranath, Kalpana, Rao, Satyajeet, Oravetzova, Anna, Dobrovolna, J., Kanagaraj, R., Chappidi, Nagaraja, Nascakova, Zuzana, Stoy, H., Lopes, M.   +12 more
core   +1 more source