Results 31 to 40 of about 6,289 (112)

Copper(I)-nitrene platform for chemoproteomic profiling of methionine

Nature Communications
Methionine plays a critical role in various biological and cell regulatory processes, making its chemoproteomic profiling indispensable for exploring its functions and potential in protein therapeutics.
Samrat Sahu, Benjamin Emenike, Christian Michel Beusch, Pritha Bagchi, David Ezra Gordon, Monika Raj   +5 more
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ROS-activated CD147-type I interferon signaling axis drives vascular smooth muscle cell fate transition and abdominal aortic aneurysm progression

Redox Biology
The transition of healthy contractile vascular smooth muscle cells to an inflammatory and senescent phenotype is a key driver of abdominal aortic aneurysm (AAA).
Fangyuan Zhong, Hengyuan Zhang, Xinning Guo, Yichao Zhao, Yufei Wang, Wenli Li, Yuyan Lyu, Heng Ge, Xiyuan Lu, Jun Pu   +9 more
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Searching for Novel Candidate Biomarkers of RLS in Blood by Proteomic Analysis

Nature and Science of Sleep, 2021
Stefania Mondello,1 Firas H Kobeissy,2 Yehia Mechref,2 Jingfu Zhao,3 Samer El Hayek,4 Kazem Zibara,5 Monica Moresco,6,7 Giuseppe Plazzi,6 Filomena II Cosentino,8 Raffaele Ferri8 1Department of Biomedical and Dental Sciences and Morphofunctional Imaging ...
Mondello S, Kobeissy FH, Mechref Y, Zhao J, El Hayek S, Zibara K, Moresco M, Plazzi G, Cosentino FII, Ferri R   +9 more
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Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases

Microbiome
Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most efficient therapeutic options available to cure many hematological malignancies.
Alejandro Artacho, Cintya González-Torres, Nuria Gómez-Cebrián, Paula Moles-Poveda, Javier Pons, Nuria Jiménez, María Jinglei Casanova, Juan Montoro, Aitana Balaguer, Marta Villalba, Pedro Chorão, Leonor Puchades-Carrasco, Jaime Sanz, Carles Ubeda   +13 more
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Integrated transcriptomic and metabolomic profiling reveals coordinated regulatory networks associated with mosaic disease resistance in sugarcane

Frontiers in Plant Science
IntroductionSugarcane mosaic disease (SCMD) poses a severe threat to global sugarcane yield. Since conventional field management is insufficient to restrict viral transmission, unraveling the underlying defense mechanisms is imperative for targeted ...
Mingjie You, Mingjie You, Hui Li, Hui Li, Yan Xie, Yan Xie, Ze Liu, Ze Liu, Xuelu Wei, Xuelu Wei, Jiahe Wu, Jiahe Wu, Yi Xu, Qing Zhang, Qing Zhang, Jisen Zhang, Jisen Zhang, Qiutao Xu, Qiutao Xu, Heyang Shang, Heyang Shang   +20 more
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The protective role of vitamin C in diabetic retinopathy and TPT1 as a potential therapeutic target

Nutrition & Metabolism
Background Diabetic retinopathy (DR), the primary driver of preventable vision impairment in the global working-age demographic, arises from chronic hyperglycaemia and manifests as non-proliferative or proliferative retinopathy with or without diabetic ...
Yuanyuan Zhang, Jiaxin Li, Xiaorong Li, Yan Shao   +3 more
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Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy (MecROX): An observational study protocol for mechanistic evaluation [version 2; peer review: 2 approved]

NIHR Open Research
Background MecROX is a mechanistic sub-study of the UK-ROX trial which was designed to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care.
Ahilanandan Dushianthan, Paul Mouncey, Daniel Martin, Lamprini Lampro, Tasnin Shahid, Victoria Goss, Amelia Francis Johnson, William Herbert, Angelica Cazley, Mark Lamond, William Jones, Karen Salmon, Florence Neyroud, Magdalena Minnion, Julian Lentaigne, Grielof Koster, Madhuri Panchal, Anthony D Postle, Helen Moyses, Michael P W Grocott, Martin Feelisch   +20 more
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Ropivacaine Inhibits Cell Proliferation, Migration and Invasion, Whereas Induces Oxidative Stress and Cell Apoptosis by circSCAF11/miR-145-5p Axis in Glioma

Cancer Management and Research, 2020
Danqin Yin,1,* Li Liu,2,* Zhengyuan Shi,1 Lihui Zhang,3 Yan Yang4 1Department of Anesthesiology, Danyang People’s Hospital of Jiangsu, Danyang City, Jiangsu Province, People’s Republic of China; 2Department of Anesthesiology, Tianjin Fourth ...
Yin D, Liu L, Shi Z, Zhang L, Yang Y
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Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma

Journal of Experimental & Clinical Cancer Research
Background About 50% of cutaneous melanoma (CM) harbors the activating BRAFV600 mutation which exerts most of the oncogenic effects through the MAPK signaling pathway.
Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Annamaria Salvati, Giovanni Nassa, Jessica Lamberti, Domenico Memoli, Patrizia Sabatelli, Marina Comelli, Arianna Bellazzo, Albina Fejza, Lucrezia Camicia, Lorena Baboci, Michele Dal Bo, Alessia Covre, Tuula A. Nyman, Alessandro Weisz, Agostino Steffan, Michele Maio, Luca Sigalotti, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta   +23 more
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Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells

Drug Design, Development and Therapy, 2015
Jia-Xuan Qiu,1,2 Zhi-Wei Zhou, 3,4 Zhi-Xu He,4 Ruan Jin Zhao,5 Xueji Zhang,6 Lun Yang,7 Shu-Feng Zhou,3,4 Zong-Fu Mao11School of Public Health, Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Department of Oral and Maxillofacial ...
Qui JX, Zhou ZW, He ZX, Zhao RJ, Zhang X, Yang L, Zhou SF, Mao ZF   +7 more
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