Results 11 to 20 of about 6,289 (112)

Systems redox biology in health and disease

EXCLI Journal : Experimental and Clinical Sciences, 2022
Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges.
Martin Feelisch, Miriam M. Cortese-Krott, Jérôme Santolini, Stephen A. Wootton, Alan A. Jackson   +4 more
doaj   +1 more source

Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease

Medicina, 2023
Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity.
Melvin R. Hayden
doaj   +1 more source

Direct cardiac effects of SGLT2 inhibitors

Cardiovascular Diabetology, 2022
Sodium-glucose-cotransporter 2 inhibitors (SGLT2is) demonstrate large cardiovascular benefit in both diabetic and non-diabetic, acute and chronic heart failure patients.
Sha Chen, Ruben Coronel, Markus W. Hollmann, Nina C. Weber, Coert J. Zuurbier   +4 more
doaj   +1 more source

Analysis using top‐k skyline query of protein‐protein interaction reveals alpha‐synuclein as the most important protein in Parkinson’s disease

Indonesian Journal of Biotechnology, 2021
Parkinson’s disease is the second‐most‐common neurodegenerative disorder and can reduce patients’ quality of life. The disease is caused by abnormalities in dopaminergic neurons, such as reactive oxygen species (ROS) imbalance leading to programmed cell ...
Mohammad Romano Diansyah, Annisa Annisa, Wisnu Ananta Kusuma   +2 more
doaj   +1 more source

Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles

Antioxidants, 2023
Although circadian biorhythms of mitochondria and cells are highly conserved and crucial for the well-being of complex animals, there is a paucity of studies on the reciprocal interactions between oxidative stress, redox modifications, metabolism ...
Richard B. Richardson, Ryan J. Mailloux
doaj   +1 more source

Comparative Proteomics Unveils LRRFIP1 as a New Player in the DAPK1 Interactome of Neurons Exposed to Oxygen and Glucose Deprivation

Antioxidants, 2020
Death-associated protein kinase 1 (DAPK1) is a pleiotropic hub of a number of networked distributed intracellular processes. Among them, DAPK1 is known to interact with the excitotoxicity driver NMDA receptor (NMDAR), and in sudden pathophysiological ...
Núria DeGregorio-Rocasolano, Verónica Guirao, Jovita Ponce, Marc Melià-Sorolla, Alicia Aliena-Valero, Alexia García-Serran, Juan B. Salom, Antoni Dávalos, Octavi Martí-Sistac, Teresa Gasull   +9 more
doaj   +1 more source

Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain

Redox Biology, 2023
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be almost exclusively ...
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor   +11 more
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FRI0426 Response of the reactive species interactome to hypothermia induced raynaud's attack in primary raynaud and systemic sclerosis [PDF]

Annals of the Rheumatic Diseases, 2018
Background Although the exact etiology of systemic sclerosis (SSc) remains unknown, a current hypothesis is that reactive species (including reactive oxygen species (ROS), reactive nitrogen species (RNS and reactive sulfur species (RSS)) play an important role in the pathogenesis.
Abdulle, A. Eman, van Roon, A.M., Smit, A.J., Pasch, A., van Meurs, M., Bootsma, H., Fernandez, B.O., Feelisch, M., van Goor, H., Mulder, D.J.   +9 more
openaire   +2 more sources

Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study

Antioxidants, 2022
Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20–30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility.
Anna T. Bergsma, Hui Ting Li, Jitske Eliveld, Marian L. C. Bulthuis, Annemieke Hoek, Harry van Goor, Arno R. Bourgonje, Astrid E. P. Cantineau   +7 more
doaj   +1 more source

Redox signaling and metabolism in Alzheimer's disease

Frontiers in Aging Neuroscience, 2022
Reduction and oxidation reactions are essential for biochemical processes. They are part of metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second messengers and oxidative modifications of cysteinyl (Cys) residues are key to ...
M. I. Holubiec, M. Gellert, E. M. Hanschmann   +2 more
doaj   +1 more source