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The Reactive Species Interactome - Mitochondria Axis

, 2022
From oxidative eustress and distress, to bioenergetic metabolism, and cell death, the reactive species interactome (RSI) and mitochondria are two connected metabolisms that require further investigation improving redox medicine. The step before, finding new clues needs a comprehensive discussion of the two metabolisms, and their relationship. Here, the
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Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?

Redox Biology, 2019
The chemical and functional interactions between Reactive Oxygen (ROS), Nitrogen (RNS) and Sulfur (RSS) species allow organisms to detect and respond to metabolic and environmental stressors, such as exercise and altitude exposure.
Andrew F. Cumpstey, Magdalena Minnion, Bernadette O. Fernandez, Monika Mikus-Lelinska, Kay Mitchell, Daniel S. Martin, Michael P.W. Grocott, Martin Feelisch   +7 more
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S-nitrosothiols and H2S donors: Potential chemo-therapeutic agents in cancer

Redox Biology, 2019
Nitric Oxide (NO) and Hydrogen Sulfide (H2S) are components of an “interactome”, which is defined as a redox system involving the interactions of RSS, RNS and ROS.
Adriana Karla Cardoso Amorim Reis, Arnold Stern, Hugo Pequeno Monteiro   +2 more
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Redox Conformation-Specific Protein–Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis

Antioxidants, 2020
2-Cysteine peroxiredoxins (2-CysPRX) are highly abundant thiol peroxidases in chloroplasts and play key roles in reactive oxygen species (ROS) defense and redox signaling.
Michael Liebthal, Johannes Schuetze, Anna Dreyer, Hans-Peter Mock, Karl-Josef Dietz   +4 more
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Manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) represses sulfide:quinone oxidoreductase expression and targets the sulfido-redox system in glioblastoma models

Redox Report
Background: The adaptation of the redox system and bioenergetics is a major factor contributing to cancer metabolism. Redox therapy is promising but still requires molecular studies that consider the reactive species interactome (RSI) concept, which ...
Elise Malard, Benoît Bernay, Jérôme Toutain, Samantha Ballesta, Marie Lévêque, Julien Pontin, Samuel Valable, Myriam Bernaudin, Laurent Chatre   +8 more
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Feedback between p21 and reactive oxygen production is necessary for cell senescence

Molecular Systems Biology, 2010
Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism.
João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki   +13 more
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Rab11b is necessary for mitochondrial integrity and function in gut epithelial cells

Frontiers in Cell and Developmental Biology
IntroductionThe RAB11 family of small GTPases are intracellular regulators of membrane and vesicular trafficking. We recently reported that RAB11A and RAB11B redundantly regulate spindle dynamics in dividing gut epithelial cells.
Ivor Joseph, Jiangmeng Han, Jared Bianchi-Smak, Jiaxing Yang, Jagannatham Naidu Bhupana, Jagannatham Naidu Bhupana, Juan Flores, Jack Delucia, Tracy S. Tran, James R. Goldenring, Edward M. Bonder, Nan Gao, Nan Gao   +12 more
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A Novel Approach for Screening Salinity-Tolerant Rice Germplasm by Exploring Redox-Regulated Cytological Fingerprint

Rice Science
Although metabolic homeostasis disruption, cellular damage, and premature senescence caused by salinity stress are well-documented in the literature, there are few studies investigating cytological changes induced by salinity stress within the altered ...
Uthpal Krishna Roy, Babita Pal, Soumen Bhattacharjee   +2 more
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A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome

Redox Biology, 2018
Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, and numerous analytical methods exist for the measurement of the sulfur-containing species affected.
T.R. Sutton, M. Minnion, F. Barbarino, G. Koster, B.O. Fernandez, A.F. Cumpstey, P. Wischmann, M. Madhani, M.P. Frenneaux, A.D. Postle, M.M. Cortese-Krott, M. Feelisch   +11 more
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Mapping the Interactome of KRAS and Its G12C/D/V Mutants by Integrating TurboID Proximity Labeling with Quantitative Proteomics

Biology
KRAS mutations are major drivers of human cancers, yet how distinct mutations rewire protein interactions and metabolic pathways to promote tumorigenesis remains poorly understood.
Jiangwei Song, Busong Wang, Mingjie Zou, Haiyuan Zhou, Yibing Ding, Wei Ren, Lei Fang, Jingzi Zhang   +7 more
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