Results 121 to 130 of about 1,419,767 (285)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Synergistic Effects in Co-Gasification of Willow and Cedar Blended Char in CO₂ Media

Energies
Willow is a promising biomass resource for addressing the challenges of securing stable domestic biomass fuels in Japan and utilising abandoned agricultural land.
Kenji Koido, Kenji Endo, Hidetsugu Morimoto, Hironori Ohashi, Michio Sato   +4 more
doaj   +1 more source

Age-dependent sensitization to the 7S-vicilin-like protein Cor a 11 from hazelnut (Corylus avellana) in a birch-endemic region [PDF]

, 2012
Background: Hazelnut (Corylus avellana) allergy exhibits age and geographically distinct sensitization patterns that have not yet been fully resolved. Objective: To study sensitization to Cor a 11 in different age groups of hazelnut-allergic patients and
Bridts, CH, Cucu, Tatiana, De Clerck, LS, De Meulenaer, Bruno, Devreese, Bart, Ebo, DG, Hagendorens, MM, Trashin, Stanislav, Verweij, MM   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards Construction of the “Periodic Table” of 1-Methylbenzotriazole

Inorganics
Metal complexes of benzotriazole-type ligands continue to attract the intense interest of many inorganic chemistry groups around the world for a variety of reasons, including their aesthetically beautiful structures, physical properties and applications.
Christina Stamou, Zoi G. Lada, Sophia Paschalidou, Christos T. Chasapis, Spyros P. Perlepes   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Investigating adverse daily life effects following a psychosocial laboratory stress task, and the moderating role of Psychopathology

Stress
Laboratory stress tasks are necessary to closely investigate the stress response in a controlled environment. However, to our knowledge, no study has tested whether participating in such tasks can pose any daily life adverse effect.
Joana De Calheiros Velozo, Thomas Vaessen, Stephan Claes, Inez Myin-Germeys   +3 more
doaj   +1 more source

Preliminary assessment of various additives on the specific reactivity of anti- rHBsAg monoclonal antibodies [PDF]

, 2015
Background: Antibodies have a wide application in diagnosis and treatment. In order to maintain optimal stability of various functional parts of antibodies such as antigen binding sites, several approaches have been suggested.
Mohammadi, S., Shokri, F., Yazdani, Y., Yousefi, M.   +3 more
core  

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Separation of river network–scale nitrogen removal among the main channel and two transient storage compartments [PDF]

, 2011
Transient storage (TS) zones are important areas of dissolved inorganic nitrogen (DIN) processing in rivers. We assessed sensitivities regarding the relative impact that the main channel (MC), surface TS (STS), and hyporheic TS (HTS) have on network ...
Briggs, Martin A., Gooseff, Michael N., Hopkinson, Charles S., Jacobs, Jennifer M., Peterson, Bruce J., Stewart, Robert J., Wollheim, Wilfred M.   +6 more
core   +1 more source