Results 11 to 20 of about 4,178,128 (285)

Towards systematic read-across using Generalised Read-Across (GenRA) [PDF]

Computational Toxicology, 2023
Poster for QSAR on June 5-9, 2023 in Copenhagen, Denmark Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=
Grace Patlewicz, Imran Shah
exaly   +4 more sources

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across [PDF]

Frontiers in Pharmacology, 2022
Chemical structure-based read-across represents a promising method for chemical toxicity evaluation without the need for animal testing; however, a chemical structure is not necessarily related to toxicity. Therefore, in vitro studies were often used for
Yuto Amano, Masayuki Yamane, Hiroshi Honda   +2 more
doaj   +2 more sources

Toward Good Read-Across Practice (GRAP) guidance. [PDF]

ALTEX, 2016
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments.
Ball, N, Blackburn, K, Booth, ED, Bouhifd, M, Cronin, MTD, Donley, E, Egnash, L, Hartung, T, Hastings, C, Juberg, DR, Kleensang, A, Kleinstreuer, N, Kroese, ED, Lee, AC, Luechtefeld, T, Maertens, A, Marty, S, Naciff, JM, Palmer, J, Pamies, D, Patlewicz, G, Penman, M, Richarz, AN, Russo, DP, Shen, J, Stuard, SB, van Ravenzwaay, B, Wu, S, Zhu, H   +28 more
core   +12 more sources

Contribution of statistical learning in learning to read across languages. [PDF]

PLoS ONE
Statistical Learning (SL) refers to human's ability to detect regularities from environment Kirkham, N. Z. (2002) & Saffran, J. R. (1996). There has been a growing interest in understanding how sensitivity to statistical regularities influences learning ...
Jinglei Ren, Min Wang
doaj   +2 more sources

Guidance on the use of read‐across for chemical safety assessment in food and feed [PDF]

EFSA Journal
Read‐across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances.
EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Pikka Jokelainen, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Edoardo Villa, Holger Zorn, Emilio Benfenati, Romualdo Benigni, Qasim Chaudhry, Lucian Farcal, George Kass, Alexis Nathanail, Alicia Paini, Rositsa Serafimova   +26 more
doaj   +2 more sources

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data [PDF]

Frontiers in Pharmacology
The development of new approach methodologies (NAMs) for next-generation risk assessment (NGRA) requires the integration of diverse data streams. A comprehensive understanding of a chemical’s potential hazard involves combining multiple mechanistic data,
Austin Ross, Vijay Gombar, Alexander Sedykh, Adrian J. Green, Alexandre Borrel, Brian Kidd, Jason Phillips, Mihir Shah, Dhiral Phadke, Deepak Mav, Michelle Balik-Meisner, Brian Howard, Ruchir Shah, Nicole C Kleinstreuer, Warren Michael Casey   +14 more
doaj   +2 more sources

In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR [PDF]

Frontiers in Pharmacology, 2019
A plethora of databases exist online that can assist in in silico chemical or drug safety assessment. However, a systematic review and grouping of databases, based on purpose and information content, consolidated in a single source, has been lacking.
Gopal Pawar, Judith C. Madden, David Ebbrell, James W. Firman, Mark T. D. Cronin   +4 more
doaj   +2 more sources

Are synthetic glucocorticoids in the aquatic environment a risk to fish?

Environment International, 2022
The glucocorticosteroid, or glucocorticoid (GC), system is largely conserved across vertebrates and plays a central role in numerous vital physiological processes including bone development, immunomodulation, and modification of glucose metabolism and ...
Charles M. Hamilton, Matthew J. Winter, Luigi Margiotta-Casaluci, Stewart F. Owen, Charles R. Tyler   +4 more
doaj   +1 more source

Nanoparticle surface coatings produce distinct antibacterial effects that are consistent across diverse bacterial species

Frontiers in Toxicology, 2023
Nanoparticles have been proposed as tunable delivery vehicles for targeted treatments and, in some cases, the active therapeutic agents themselves. Despite the promise of such customizable impacts, little evidence exists to support these claims in the ...
Thelma Ameh, Kuzy Zarzosa, Kuzy Zarzosa, W. Evan Braswell, Christie M. Sayes   +4 more
doaj   +1 more source

Grouping MWCNTs based on their similar potential to cause pulmonary hazard after inhalation: a case-study

Particle and Fibre Toxicology, 2022
Background The EU-project GRACIOUS developed an Integrated Approach to Testing and Assessment (IATA) to support grouping high aspect ratio nanomaterials (HARNs) presenting a similar inhalation hazard.
Fiona Murphy, Nicklas Raun Jacobsen, Emilio Di Ianni, Helinor Johnston, Hedwig Braakhuis, Willie Peijnenburg, Agnes Oomen, Teresa Fernandes, Vicki Stone   +8 more
doaj   +1 more source