Results 81 to 90 of about 1,607,683 (337)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Investigating the Relationship Between Oral Reading Miscues and Comprehension in L2 Chinese

Languages
Reading comprehension in Chinese as a second language (L2 Chinese) presents unique challenges due to the language’s logographic writing system. Analysis of oral reading miscues reveals specific patterns in L2 learners’ reading processes and comprehension
Sicheng Wang
doaj   +1 more source

TASK-BASED LANGUAGE TEACHING (TBLT) APPROACH: IMPLICATIONS ON READING COMPREHENSION

Eternal (English, Teaching, Learning & Research Journal), 2020
Task-based language teaching (TBLT) has exceedingly been written in many research reports but research examining the impacts of TBLT on student’s reading comprehension remains limited.
Achmad Taqlidul Chair Fachruddin
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Evaluating the Simple View of Reading Model: Longitudinal Testing and Applicability to the Swedish Language

Education Sciences
This study investigates the empirical validity of the simple view of reading model in a semi-transparent language, Swedish, by using a large amount of reading test data from 11,791 students. Data were collected during the primary grades (year 1–3), which
Thomas Nordström, Linda Fälth, Henrik Danielsson   +2 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Reading Comprehension Ability Test-A Turing Test for Reading Comprehension

, 2019
Reading comprehension is an important ability of human intelligence. Literacy and numeracy are two most essential foundation for people to succeed at study, at work and in life. Reading comprehension ability is a core component of literacy. In most of the education systems, developing reading comprehension ability is compulsory in the curriculum from ...
Miao, Yuan, Lin, Gongqi, Hu, Yidan, Miao, Chunyan   +3 more
openaire   +2 more sources

Gated Self-Matching Networks for Reading Comprehension and Question Answering

Annual Meeting of the Association for Computational Linguistics, 2017
In this paper, we present the gated self-matching networks for reading comprehension style question answering, which aims to answer questions from a given passage.
Wenhui Wang, Nan Yang, Furu Wei, Baobao Chang, M. Zhou   +4 more
semanticscholar   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source