Results 91 to 100 of about 115,064,647 (297)

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

A cross-linguistic evaluation of script-specific effects on fMRI lateralization in late second language readers

Frontiers in Human Neuroscience, 2014
Behavioral and neuroimaging studies have provided evidence that reading is strongly left lateralized, and this pattern of functional lateralization can be indicative of reading competence.
Maki Sophia Koyama, Maki Sophia Koyama, John Frederick Stein, Catherine J Stoodley, Peter C Hansen   +4 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

L2 creative writers : identities and writing processes [PDF]

L2 creative writing research is a relatively unchartered area. Pedagogical discussions on L2 creative writing activities often focus on manifestations of L2 learners' language learning, writing improvement, or expressions of emotion.
Zhao, Yan, Ph.D.
core  

Pre-task planning, working memory capacity, and L2 speech performance [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura CorrespondenteAs pesquisas sobre o planejamento dentro da abordagem de ensino baseado em tarefas ...
Tavares, Maria da Glória Guará
core  

Decoding intervention for L2 students in Sweden [Elektronisk resurs] : A single-subject design study

, 2023
Many second language (L2) students in Sweden struggle with reading in Swedish. There needs to be more research on how L2 students with weak word decoding skills in Swedish could be individually supported.
Fälth, Linda, Svensson, Idor, Selenius, Heidi,, Egerhag, Helén   +3 more
core  

COMMENTARY: CAN FREE READING TAKE YOU ALL THE WAY? A RESPONSE TO COBB (2007) [PDF]

Language Learning and Technology, 2008
Cobb (2007) argues that free reading cannot provide L2 readers with sufficient opportunities for acquiring vocabulary in order to reach an adequate level of reading comprehension of English texts.
Jeff McQuillan, Stephen D. Krashen
doaj  

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Are alphabetic language -derived models of L2 reading relevant to L1 logographic background readers?

, 2012
In this paper, we argue that second language (L2) reading research, which has been informed by studies involving first language (L1) alphabetic English reading, may be less relevant to L2 readers with non-alphabetic reading backgrounds, such as Chinese ...
Ehrich, John Fitzgerald, Lisa Catherine Ehrich, Jon Congjun Mu, Ehrich, Lisa C., Mu, Jon Congjun, Zhang, Jun Lawrence, Lawrence Jun Zhang, Zhang, Lawrence Jun, Ehrich, Lisa Catherine, John Fitzgerald Ehrich   +9 more
core   +1 more source