Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
Upper elementary students' self-efficacy, affect, and avoidance associated with multisyllabic words: an exploratory study. [PDF]
Traga Philippakos ZA, Quinn M, Davis A.
europepmc +1 more source
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley +1 more source
Evaluating correlates of healthy eating and dietary quality among older adults: a mixed methods approach to development and application of a new survey instrument. [PDF]
Rosenkranz SK +5 more
europepmc +1 more source
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee +17 more
wiley +1 more source
Longitudinal associations between gaming and academic motivation during middle childhood. [PDF]
Tiraboschi GA +5 more
europepmc +1 more source
His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
How Does Teacher Certification Promote Student Achievement in Science, Reading, and Math? A Chain-Mediated Model of Teachers' Sense of Efficacy and Pedagogical Innovation. [PDF]
Guo Y, Tian G.
europepmc +1 more source

