Results 71 to 80 of about 1,255,141 (291)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Reading Assessment and Eye Movement Analysis in Bilateral Central Scotoma Due to Age-Related Macular Degeneration

Journal of Eye Movement Research
This study investigates reading performances and eye movements in individuals with eccentric fixation due to age-related macular degeneration (AMD). Overall, 17 individuals with bilateral AMD (7 males; mean age 77.47 ± 5.96 years) and 17 controls (10 ...
Polona Zaletel Benda, Grega Jakus, Jaka Sodnik, Nadica Miljković, Ilija Tanasković, Smilja Stokanović, Andrej Meglič, Nataša Vidovič Valentinčič, Polona Jaki Mekjavić   +8 more
doaj   +1 more source

Analisis Kemampuan Membaca Cepat pada Mahasiswa Tingkat II Program Studi Pendidikan Bahasa Jepang Universitas Riau Tahun Ajaran 2014/2015 [PDF]

, 2016
Abtract: Speed reading is a blend of speed reading with understanding thecontent of reading. This study aims to determine the level of reading speed, readingcomprehension, effective speed reading, and speed reading constraints in Japanese.This study used
Basri, M. S. (Merri), Irawan, I. (Indra), Widiati, S. W. (Sri)   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Differential profiles of reading development in neurodevelopmental disorders under an adapted tier 2 response to Intervention protocol

Frontiers in Pediatrics
IntroductionReading proficiency is a foundational skill. Failure to achieve reading competence constitutes a global educational and public health challenge. This burden is especially high among children with neurodevelopmental conditions.
Renata Mousinho, Fernanda Mesquita, Lia Pinheiro, Cristina Leitão, Rosinda Martins Oliveira, Felipe Pegado, Erika Carvalho Rodrigues   +6 more
doaj   +1 more source

Reading performance in children with visual function anomalies [PDF]

, 2014
Aims - To compare reading performance in children with and without visual function anomalies and identify the influence of abnormal visual function and other variables in reading ability.
Lança, Carla Costa, Prista, João, Serra, Helena   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Reading errors made by skilled and unskilled readers: evaluating a system that generates reports for people with poor literacy [PDF]

, 2004
This study evaluates a natural language generation system that creates literacy assessment reports in order to create more readable documents. Prior research assessed comprehension and reading speed on modified documents.
Reiter, Ehud, Williams, Sandra
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source