Results 91 to 100 of about 12,543 (199)

MUTYH Cancer‐Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Functional analysis of cancer‐associated variants of the DNA repair enzyme MUTYH in the interdomain connector between the 8‐oxoguanine (OG) recognition and base excision domains reveals discordance between in vitro assays and OG:A repair in cells. This disconnect highlights the use of complementary biochemical and cellular assays to accurately classify
Cindy Khuu, Melody Malek, Savannah G. Conlon, Geoffrey P. Wadey, Carlos H. Trasviña‐Arenas, Sheila S. David   +5 more
wiley   +1 more source

Readthrough Acetylcholinesterase Is Increased in Human Liver Cirrhosis

PLoS ONE, 2012
There have been many studies on plasma butyrylcholinesterase in liver dysfunction. However, no data is available about acetylcholinesterase in human cirrhosis, although profound changes have been described in cirrhotic rat models.Human serum and liver acetylcholinesterase and its molecular forms were determined enzymatically, after ...
María-Salud García-Ayllón, Cristina Millán, Carol Serra-Basante, Ramón Bataller, Javier Sáez-Valero   +4 more
openaire   +7 more sources

Characterization of sequence requirements for translational readthrough in human cells.

, 2014
(A) A reporter construct consisting of gfp and myc interrupted by a stop codon was expressed in HeLa cells. Stop codon readthrough was analyzed by detection of the myc-epitope by Western blot.
Julia Ast (650082), Alina C. Stiebler (650079), Johannes Freitag (221216), Thorsten Stehlik (650080), Britta A. M. Tillmann (650081), Michael Bölker (221220), Kay O. Schink (628123)   +6 more
core   +1 more source

Aminoglycoside potency and activity in readthrough assays.

, 2018
Aminoglycoside potency and activity in readthrough assays.
Hongyu Ren (390914), Marla Weetall (1834063), Joseph M. Colacino (1834087), Jairo Sierra (5896937), Priya Vazirani (2866859), Stuart W. Peltz (495718), Westley J. Friesen (5896931), Jin Zhuo (5896940), Christie Morrill (1834075), Xiaojiao Xue (5896943), Anna Mollin (1834057), Art Branstrom (5896952), Ramil Baiazitov (5896949), Josephine Sheedy (1834093), Ellen M. Welch (5896955), Jean Hedrick (3590069), Yuki Tomizawa (5896946), Suresh Babu (144834), Gary Elfring (495716), Briana Johnson (5896934), Young-Choon Moon (1968544)   +20 more
core   +1 more source

Decoding cancer‐associated ribosomal protein mutations: A new frontier in cancer and ribosome biology

HemaSphere, Volume 10, Issue 9, September 2026.
Mirsada Čaušević, Robbie Loewith, Siniša Volarević   +2 more
wiley   +1 more source

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

, 2016
International audienceNonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but with low ...
Krause, Alexandra, B, Jan, Eric,, Roberge, Michel,, Shidmoossavee, Fahimeh S., Tan, Jason S., Choi, Kunho, B, Balgi, Aruna,, Krause, Alexandra,, Balgi, Aruna, B, Baradaran-Heravi, Alireza, B, Pfeifer, Tom, B, Mouly, Vincent, B, Jaquith, James B., Shimizu, Yoko,, Choi, Kunho,, Bergeaud, Célia,, Roberge, Michel, B, Zimmerman, Carla, B, Pfeifer, Tom,, Mouly, Vincent,, Anderson, Hilary J., Bergeaud, Célia, B, Jan, Eric, B, Flibotte, Stéphane, Zimmerman, Carla,, Shimizu, Yoko, B, Baradaran-Heravi, Alireza,   +26 more
core   +1 more source

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons

Molecular Medicine, 2018
Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins.
Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz   +2 more
doaj   +1 more source

Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner

, 2020
Despite their essential function in terminating translation, readthrough of stop codons occurs more frequently than previously supposed. However, little is known about the regulation of stop codon readthrough by anatomical site and over the life cycle of
Javid, Babak, Chen, Yanan, Sun, Tianhui, Pastor-Pareja, José Carlos, Bi, Zhuo   +4 more
core   +1 more source

The unfolded protein response affects readthrough of premature termination codons

EMBO Molecular Medicine, 2014
One‐third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in‐frame PTCs enables synthesis of full‐length functional proteins.
Yifat S Oren, Michelle L McClure, Steven M Rowe, Eric J Sorscher, Assaf C Bester, Miriam Manor, Eitan Kerem, Joseph Rivlin, Fouad Zahdeh, Matthias Mann, Tamar Geiger, Batsheva Kerem   +11 more
doaj   +1 more source

Data from: Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

, 2013
Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila ...
Gavis, Elizabeth R., Belletier, Nicolette G., Foo, Catherine K., Weissman, Jonathan S., Dunn, Joshua G.   +4 more
core   +1 more source