Results 111 to 120 of about 12,543 (199)

Untersuchung von Translationalem Readthrough bei Peroxisomalen Biogenesestörungen im Zellmodell

Promotionskolleg für Medizinstudierende der Universitätsmedizin Göttingen, Else Kröner-Fresenius-Kolleg, Jacob-Henle-ProgrammPromotionskolleg für Medizinstudierende der Universitätsmedizin Göttingen, Else Kröner-Fresenius-Kolleg, Jacob-Henle ...
Schilff, Mirco
core   +1 more source

Stop codon readthrough in MTCH2 mRNA and its role in mitochondrial physiology

, 2020
Stop codon readthrough is the process in which translation continues beyond a stop codon till a downstream, in-frame stop codon generating a polypeptide with a C-terminal extension.
Lekha, E M
core  

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules [PDF]

Premature termination codons (PTCs) cause ~10–20% of inherited diseases and are a major mechanism of tumor suppressor gene inactivation in cancer. A general strategy to alleviate the effects of PTCs would be to promote translational readthrough. Nonsense
Supek, Fran, Lehner, Ben, 1978-, Toledano Martin, Ignasi, Toledano, Ignasi, Lehner, Ben   +4 more
core   +1 more source

Regulatory Mechanisms and Functional Roles of Readthrough Transcripts in Tumorigenesis

International Journal of Molecular Sciences
The search for novel tumor-specific markers and therapeutic targets is driving the development of more effective and personalized treatment strategies for cancer patients. This article focuses on investigating a promising new source of biomarkers—readthrough transcripts, or downstream-of-gene (DoG) transcripts.
Alexander Modestov, Galina Zakharova, Elena Poddubskaya, Anton Buzdin   +3 more
openaire   +3 more sources

Pharmacological readthrough and base editing for <i>ANK1</i> nonsense mutations in an erythroid model of hereditary spherocytosis. [PDF]

Mol Ther Nucleic Acids
Li S, Li J, Shi W, Nie Z, Zhang S, Ding X, Hu J, Li P, Xie X.   +8 more
europepmc   +1 more source

PTC124 promotes mutation site-dependent readthrough of STK11 nonsense mutations and restores tumor suppressor function. [PDF]

BBA Adv
Hung CH, Wang HH, Cheng YT, Chen JY, Lin KY, Chen ST, Pan TY, Lin HJ, Chen CC, Cai BH.   +9 more
europepmc   +1 more source

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: Second Edition. [PDF]

Viruses
Hellen CUT.
europepmc   +1 more source

Immunogenic implications of translational readthrough modulate the association of F8 nonsense mutations with inhibitors in Hemophilia A. [PDF]

Mol Med
Testa MF, Pinotti M, Branchini A, Mancuso ME, Bernardi F, Balestra D.   +5 more
europepmc   +1 more source

Expanded Genomic Diversity of Cacao Leafroll Virus Enables Improved Detection Using Multiplex RT-PCR. [PDF]

Pathogens
Ullah I, Kamran M, Daymond AJ, Dunwell JM.   +3 more
europepmc   +1 more source

Engineered suppressor tRNAs enable precise translational control of genetic circuits in E. coli. [PDF]

Nucleic Acids Res
Wang X, Xu J, Wang Y, Qi Q, Wang Z, Wang Q.   +5 more
europepmc   +1 more source