Results 121 to 130 of about 12,504 (200)

Investigating stop codon readthrough in Saccharomyces cerevisiae

, 2021
Stop codon readthrough occurs via genetic and epigenetic mechanisms, resulting in a longer polypeptide chain at the C-terminus. Although these readthroughs may seem like an error made by translational mechanisms, evidence from yeast suggests that stop codon readthrough has an impact on various cellular processes. Readthrough has the potential to create
openaire   +1 more source

Anticodon-edited tRNA enables translational readthrough of COL4A5 premature termination codons. [PDF]

PLoS One
Omachi K, Porter JJ, Lueck JD, Miner JH.
europepmc   +1 more source

Substitutions in RNA-binding protein Hrp1 map a potential interaction surface with the yeast RNA polymerase II elongation complex. [PDF]

Genetics
Wang M, Arora P, Kaplan CD, Brow DA.
europepmc   +1 more source

Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart development. [PDF]

Cardiovasc Res
Zhang Z, Wu T, Chen Z, Chen D, Liang Z, Adams C, Gu Y, Ye M, Barroga F, Evans S, Zhou X, Chen J.   +11 more
europepmc   +1 more source

Protein C-terminal variations impact proteostasis. [PDF]

Nat Commun
Chu CY, Hsu SY, Yeh CW, Yeh KH, Wang LC, Lee LT, Chen SC, Yu CH, Yen HS.   +8 more
europepmc   +1 more source

Glc7/PP1 triggers Paf1 complex dissociation from RNA polymerase II to enable transcription termination. [PDF]

Genes Dev
Namjilsuren S, Arndt KM.
europepmc   +1 more source

Recovery of α-L-fucosidase in fucosidosis nonsense variants by readthrough stimulation and release factor degradation. [PDF]

Dis Model Mech
Bäumges H, Lebeda D, Deppe P, Ilse MB, Thoms S, Lübke T.   +5 more
europepmc   +1 more source

Eukaryotic initiation factor eIF3 facilitates loading of eukaryotic release factor eRF1 or suppressor tRNA to the ribosome. [PDF]

Nucleic Acids Res
Shuvalova E, Shuvalov A, Al Sheikh W, Klishin A, Biziaev N, Alkalaeva E.   +5 more
europepmc   +1 more source

RFFL-mediated protein quality control limits functional rescue of TRID-CFTR modulator combination therapy for cystic fibrosis nonsense mutations. [PDF]

Cell Mol Life Sci
Tateishi H, Doi Y, Kamada Y, Okiyoneda T.   +3 more
europepmc   +1 more source

Translational readthrough therapy for ADPKD induces polycystin1 expression and partially rescues functional deficits in PKD1 mutant cells. [PDF]

Sci Rep
Torban E, Canaff L, Babayeva S, Kachurina N, Chung CF, Ong ACM, Alam A, Goodyer PR.   +7 more
europepmc   +1 more source