Results 101 to 110 of about 12,543 (199)

Interrogation of Eukaryotic Stop Codon Readthrough Signals by in Vitro RNA Selection

, 2019
RNA signals located downstream of stop codons in eukaryotic mRNAs can stimulate high levels of translational readthrough by the ribosome, thereby giving rise to functionally distinct C-terminally extended protein products.
Raul Rabadan (88130), Sakellarios Zairis, Andrew V. Anzalone (2245570), Raul Rabadan, Sakellarios Zairis (813849), Annie J. Lin, Virginia W. Cornish, Annie J. Lin (6326279), Virginia W. Cornish (1265385), Andrew V. Anzalone   +9 more
core   +1 more source

Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature Termination Codons

Pharmaceuticals
Nonsense mutations that generate a premature termination codon (PTC) can induce both the accelerated degradation of mutated mRNA compared with the wild type version of the mRNA or the production of a truncated protein.
Nesrine Benslimane, Camille Loret, Pauline Chazelas, Frédéric Favreau, Pierre-Antoine Faye, Fabrice Lejeune, Anne-Sophie Lia   +6 more
doaj   +1 more source

The genetic architecture of human programmed stop codon readthrough

Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs.
Ignasi Toledano, Ben Lehner, Fran Supek
core   +1 more source

Misincorporations of amino acids in p53 in human cells at artificially constructed termination codons in the presence of the aminoglycoside Gentamicin

Frontiers in Genetics
Readthrough of a translation termination codon is regulated by ribosomal A site recognition and insertion of near-cognate tRNAs. Small molecules exist that mediate incorporation of amino acids at the stop codon and production of full-length, often ...
Kamila Pawlicka, Tomas Henek, Lukas Uhrik, Lenka Hernychova, Monikaben Padariya, Jakub Faktor, Sławomir Makowiec, Borivoj Vojtesek, Borivoj Vojtesek, David Goodlett, Ted Hupp, Ted Hupp, Umesh Kalathiya   +12 more
doaj   +1 more source

Dual Reporter Systems for the Analysis of Translational Readthrough in Mammals

, 2017
Translational readthrough, the decoding of stop codons as sense codons, leads to C-terminal extension of proteins which may lead to the formation of protein isoforms with distinct properties from the original protein. Two proteins have recently been identified that are targeted to the peroxisome via hidden peroxisomal targeting signals in their ...
Hofhuis, Julia, Dieterle, Severin, George, Rosemol, Schueren, Fabian, Thoms, Sven, Schrader, M.   +5 more
openaire   +3 more sources

Intrinsic and Extrinsic Factors for Natural Killer Cells and Their Involvement in Behcet Disease

Rheumato
This study is a narrative review of natural killer (NK) cells in Behcet disease (BD). BD is an inflammatory disorder with manifestations in mucosal tissues. Unlike autoimmune diseases that generate autoantibodies, BD is believed to be an autoinflammatory
Yasuhiro Omata
doaj   +1 more source

Correction: Functional Translational Readthrough: A Systems Biology Perspective

PLOS Genetics, 2016
[This corrects the article DOI: 10.1371/journal.pgen.1006196.].
openaire   +3 more sources

PTC readthrough [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity

(+)-Negamycin, which is a dipeptide-like antibiotic containing a hydrazide structure, exhibits readthrough activity, resulting in the restoration of dystrophin in the mdx mouse model of Duchenne muscular dystrophy (DMD).
Tomoki Kuwahara (565470), Toshifumi Nomura (426349), Noriko Omura (7451477), Keisuke Hamada (1671418), Atsuhiko Taniguchi (2653804), Mizuki Watanabe (1874182), Masanori Nakakuki (17547861), Kentaro Takayama (668079), Satoshi Shuto (102368), Yoshio Hayashi (111974), Akihiro Taguchi (1639003), Sho Konno (1456381)   +11 more
core   +1 more source

Programmed Translational Readthrough in Drosophila melanogaster [PDF]

, 2022
openaire   +2 more sources