ARTDeco: automatic readthrough transcription detection [PDF]
BMC Bioinformatics, 2020 Background Mounting evidence suggests several diseases and biological processes target transcription termination to misregulate gene expression. Disruption of transcription termination leads to readthrough transcription past the 3′ end of genes, which ...
Samuel J. Roth +2 more
doaj +7 more sources
Variable readthrough responsiveness of nonsense mutations in hemophilia A [PDF]
Haematologica, 2020 Readthrough therapy relies on the use of small molecules that enable premature termination codons in mRNA open reading frames to be misinterpreted by the translation machinery, thus allowing the generation of full-length, potentially functional proteins ...
Lluis Martorell +4 more
doaj +5 more sources
Evaluation of gliovascular functions of AQP4 readthrough isoforms
Frontiers in Cellular Neuroscience, 2023 Aquaporin-4 (AQP4) is a water channel protein that links the astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise ...
Shayna M. Mueller +31 more
doaj +5 more sources
Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae.
PLoS Genetics, 2021 Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release.
Kotchaphorn Mangkalaphiban +5 more
doaj +2 more sources
Deciphering the molecular mechanism of stop codon readthrough [PDF]
Biological Reviews, 2020 International audienceRecognition of the stop codon by the translation machinery is essential to terminating 12 translation at the right position and to synthesizing a protein of the correct size.
Palma, Martine +3 more
core +4 more sources
The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. [PDF]
PLoS ONE, 2019 Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to truncated p53 protein with impaired function.
Michael W Ferguson +9 more
doaj +3 more sources
Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax [PDF]
Cell, 2014 SummaryTranslational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon.
Koch, William J. +9 more
core +4 more sources
Nonaminoglycoside compounds induce readthrough of nonsense mutations [PDF]
Journal of Experimental Medicine, 2009 Large numbers of genetic disorders are caused by nonsense mutations for which compound-induced readthrough of premature termination codons (PTCs) might be exploited as a potential treatment strategy.
Henning, Susanne M +21 more
core +6 more sources
DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq
BMC Genomics, 2018 Background Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells.
Yuval Wiesel, Niv Sabath, Reut Shalgi
doaj +2 more sources
Functional Translational Readthrough: A Systems Biology Perspective.
PLOS Genetics, 2016 Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR).
Fabian Schueren +3 more
core +6 more sources