Results 31 to 40 of about 12,504 (200)

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential. [PDF]

PLoS ONE, 2018
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are responsible for thousands of inherited diseases. Readthrough of premature stop codons by small molecule drugs has emerged as a promising therapeutic approach ...
Westley J Friesen, Briana Johnson, Jairo Sierra, Jin Zhuo, Priya Vazirani, Xiaojiao Xue, Yuki Tomizawa, Ramil Baiazitov, Christie Morrill, Hongyu Ren, Suresh Babu, Young-Choon Moon, Art Branstrom, Anna Mollin, Jean Hedrick, Josephine Sheedy, Gary Elfring, Marla Weetall, Joseph M Colacino, Ellen M Welch, Stuart W Peltz   +20 more
doaj   +1 more source

Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough.

PLoS Biology, 2021
Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins.
Sara Hosseini-Farahabadi, Alireza Baradaran-Heravi, Carla Zimmerman, Kunho Choi, Stephane Flibotte, Michel Roberge   +5 more
doaj   +1 more source

Chromatin profiling identifies transcriptional readthrough as a conserved mechanism for piRNA biogenesis in mosquitoes.

Cell Reports, 2023
The piRNA pathway in mosquitoes differs substantially from other model organisms, with an expanded PIWI gene family and functions in antiviral defense.
J. Qu, Valerie Betting, Ruben van Iterson, Florence M. Kwaschik, R. V. van Rij   +4 more
semanticscholar   +1 more source

Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells. [PDF]

PLoS ONE, 2011
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutations accounting for 30% of all mutations in this gene.
Célia Floquet, Jean-Pierre Rousset, Laure Bidou   +2 more
doaj   +1 more source

Seryl-tRNA synthetase promotes translational readthrough by mRNA binding and involvement of the selenocysteine incorporation machinery

Nucleic Acids Research, 2023
Translational readthrough of UGA stop codons by selenocysteine-specific tRNA (tRNASec) enables the synthesis of selenoproteins. Seryl-tRNA synthetase (SerRS) charges tRNASec with serine, which is modified into selenocysteine and delivered to the ribosome
Ze Liu, Justin Wang, Yi Shi, Brian A. Yee, M. Terrey, Qian Zhang, Jenq-Chang Lee, Kuo-I Lin, A. H. Wang, Susan L. Ackerman, Gene W. Yeo, Haissi Cui, Xiang-Lei Yang   +12 more
semanticscholar   +1 more source

A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay. [PDF]

PLoS ONE, 2017
The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins.
Stacey L Baker, J Robert Hogg
doaj   +1 more source

The synthetic aminoglycoside ELX-02 induces readthrough of G550X-CFTR producing superfunctional protein that can be further enhanced by CFTR modulators

American Journal of Physiology - Lung cellular and Molecular Physiology, 2023
Ten percent of cystic fibrosis (CF) patients carry a Premature Termination Codon (PTC); no nutation-specific therapies exist for these individuals. ELX-02, a synthetic aminoglycoside, suppresses translation termination at PTCs (i.e., readthrough) by ...
Jianguo Chen, Kari Thrasher, Lianwu Fu, Wen Wang, S. Aghamohammadzadeh, Hui Wen, L. Tang, K. Keeling, Emily Falk Libby, D. Bedwell, S. Rowe   +10 more
semanticscholar   +1 more source

Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animals. [PDF]

PLoS Genetics, 2014
Translation of mRNA into a polypeptide chain is a highly accurate process. Many prokaryotic and eukaryotic viruses, however, use leaky termination of translation to optimize their coding capacity.
Alina C Stiebler, Johannes Freitag, Kay O Schink, Thorsten Stehlik, Britta A M Tillmann, Julia Ast, Michael Bölker   +6 more
doaj   +1 more source

Investigating the Inhibition of FTSJ1, a Tryptophan tRNA-Specific 2′-O-Methyltransferase by NV TRIDs, as a Mechanism of Readthrough in Nonsense Mutated CFTR

International Journal of Molecular Sciences, 2023
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are “stop” mutations that generate a premature termination codon (PTC), thus ...
P. Carollo, M. Tutone, Giulia Culletta, I. Fiduccia, Federica Corrao, I. Pibiri, A. Di Leonardo, M. Zizzo, R. Melfi, A. Pace, A. Almerico, L. Lentini   +11 more
semanticscholar   +1 more source

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

eLife, 2013
Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila ...
Joshua G Dunn, Catherine K Foo, Nicolette G Belletier, Elizabeth R Gavis, Jonathan S Weissman   +4 more
doaj   +1 more source