Results 31 to 40 of about 12,543 (199)

Therapeutics Based on Stop Codon Readthrough [PDF]

Annual Review of Genomics and Human Genetics, 2014
Nonsense suppression therapy encompasses approaches aimed at suppressing translation termination at in-frame premature termination codons (PTCs, also known as nonsense mutations) to restore deficient protein function. In this review, we examine the current status of PTC suppression as a therapy for genetic diseases caused by nonsense mutations.
Kim M, Keeling, Xiaojiao, Xue, Gwen, Gunn, David M, Bedwell   +3 more
openaire   +2 more sources

Translation initiation factor eIF3 promotes programmed stop codon readthrough. [PDF]

, 2015
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins.
von der Haar, Tobias, Beznoskova, Petra, Wagner, Susan, Valasek, Leos S, Jansen, Myrte E   +4 more
core   +1 more source

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

eLife, 2013
Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila ...
Joshua G Dunn, Catherine K Foo, Nicolette G Belletier, Elizabeth R Gavis, Jonathan S Weissman   +4 more
doaj   +1 more source

Readthrough predictions

, 2023
Readthrough predictions for all possible nonsense mutations in the human genome for six different drugs (CC90009, Clitocine, DAP, G418, SRI and SJ6986).
Ben Lehner (9250248), Ignasi Toledano (16419720), Fran Supek (7520714)   +2 more
core   +1 more source

Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay [PDF]

, 2020
To gain insight into the mechanistic link between translation termination and nonsense-mediated mRNA decay (NMD), we depleted the ribosome recycling factor ABCE1 in human cells, resulting in an upregulation of NMD-sensitive mRNAs.
Annibaldis, Giuditta, Domanski, Michal, Contu, Lara, Kläy, Nina, Contu, L., Annibaldis, G., Carl, Sarah, Kläy, N., Dreos, R., Mühlemann, Oliver, Mühlemann, O., Domanski, M., Dreos, René, Carl, S.   +13 more
core   +2 more sources

A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons

, 2021
The PTEN tumor suppressor gene is mutated with high incidence in tumors and in thegermline of patients with cancer predisposition or with macrocephaly associatedwith autism.PTENnonsense mutations generating premature termination codons (PTC)and producing
Molina Martín, María, Jiménez Cid, Víctor, Luna, Sandra, Torices, Leire, Pulido, Rafael, Amo, Laura, López, José I., Cortés, Jesús M., Rodríguez Escudero, María Isabel, Erramuzpe, Asier, Ruiz‐Ibarlucea, Pablo, Tejada, María I., Nunes‐Xavier, Caroline E., Mingo, Janire   +13 more
core   +1 more source

Yeast applied readthrough inducing system (YARIS): an invivo assay for the comprehensive study of translational readthrough [PDF]

Nucleic Acids Research, 2019
AbstractStop codon readthrough—the decoding of a stop codon by a near-cognate tRNA—is employed by viruses to balance levels of enzymatic and structural proteins and by eukaryotic cells to enable isoform-specific protein synthesis in response to external stimuli.
Beznosková, P. (Petra), Pavlíková, Z. (Zuzana), Zeman, J. (Jakub), Aitken, C.E., Valášek, L. (Leoš Shivaya)   +4 more
openaire   +3 more sources

Computational analysis of stop codon readthrough in D.melanogaster [PDF]

Bioinformatics, 2003
Abstract Motivation: Readthrough is an unusual process in which a stop codon is misread or skipped. Recently it has been shown that some translation is regulated by the readthrough reactions although the complete mechanism is not clear.
Misaki Sato, Hitomi Umeki, Rintaro Saito, Akio Kanai, Masaru Tomita   +4 more
openaire   +2 more sources

Stops making sense: translational trade-offs and stop codon reassignment [PDF]

, 2011
Background Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons
Steven C Le Comber, Johnson, Louise J, Johnson, LJ, Le Comber Steven C, Nichols Richard A, Louise J Johnson, Polly, PD, Lichtenstein, CP, Polly p David, Cotton, James A., Le Comber, SC, p David Polly, Le Comber, Steven C., Conrad P Lichtenstein, Cotton, JA, Nichols, RA, Lichtenstein Conrad P, James A Cotton, Elgar, GS, Elgar, Greg S., Lichtenstein, Conrad P., Elgar Greg S, Nichols, Richard A., Greg S Elgar, Cotton James A, Johnson Louise J, Johnson, Louise J., Richard A Nichols, Polly, P. David   +28 more
core   +2 more sources

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control [PDF]

, 2023
Suppression of premature termination codons (PTCs) by translational readthrough is a promising strategy to treat a wide variety of severe genetic diseases caused by nonsense mutations.
Francis Bitsch, Gasser-Didierlaurent, Christelle, Markus Schirle, Galuba, Olaf, Julian Schoenbett, Xiaohong Mao, Anne-Christine Uldry, Wojciech Teodorowicz, Reinhardt, Juergen, Schmiedeberg, Niko, Teodorowicz, Wojciech, Sigoillot, Frederic, Marion Link, Frederic Sigoillot, Mühlemann, Oliver, Jana Ziegelmüller, Mao, Xiaohong, Couttet, Philippe, Couttet, Philipp, Jürgen Reinhardt, Bitsch, Francis, Oliver Mühlemann, Reinhardt, Jürgen, Christelle Gasser-Didierlaurant, Isabel Schmidt, Parker, Christian, Schirle, Markus, Niko Schmiedeberg, Ibig-Rehm, Yvonne, Muehlemann, Oliver, Gasser-Didierlaurant, Christelle, Ziegelmueller, Jana, Olaf Galuba, Yvonne Ibig, Lukas-Adrian Gurzeler, Philipp Couttet, Ibig, Yvonne, Ziegelmüller, Jana, Schoenbett, Julian, Parker, Christian N, Uldry, Anne-Christine, Link, Marion, Christian N. Parker, Gurzeler, Lukas-Adrian, Schmidt, Isabel   +44 more
core   +2 more sources