Results 21 to 30 of about 12,504 (200)
Variable readthrough responsiveness of nonsense mutations in hemophilia A
Haematologica, 2020 Readthrough therapy relies on the use of small molecules that enable premature termination codons in mRNA open reading frames to be misinterpreted by the translation machinery, thus allowing the generation of full-length, potentially functional proteins ...
Lluis Martorell +4 more
doaj +4 more sources
Deciphering the molecular mechanism of stop codon readthrough [PDF]
Biological Reviews, 2020 Recognition of the stop codon by the translation machinery is essential to terminating translation at the right position and to synthesizing a protein of the correct size.
Martine Palma, F. Lejeune
semanticscholar +4 more sources
The unfolded protein response affects readthrough of premature termination codons
EMBO Molecular Medicine, 2014 One‐third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in‐frame PTCs enables synthesis of full‐length functional proteins.
Steven M Rowe, Msph +2 more
exaly +2 more sources
Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination [PDF]
Nature CommunicationsCo-transcriptional cleavage and transcription termination are closely related processes during mRNA maturation, yet their coordination remains poorly understood due to difficulties in detecting these transient events.
Xianhao Jin +16 more
doaj +2 more sources
Cellular senescence limits translational readthrough [PDF]
Biology Open, 2021 ABSTRACT The origin and evolution of cancer cells is considered to be mainly fueled by DNA mutations. Although translation errors could also expand the cellular proteome, their role in cancer biology remains poorly understood. Tumor suppressors called caretakers block cancer initiation and progression by preventing DNA mutations and ...
Neylen del Toro +10 more
openaire +3 more sources
Cell Reports, 2023 Suppression of premature termination codons (PTCs) by translational readthrough is a promising strategy to treat a wide variety of severe genetic diseases caused by nonsense mutations.
Lukas-Adrian Gurzeler +18 more
semanticscholar +2 more sources
Cell, 2023 Summary Readthrough into the 3′ untranslated region (3′ UTR) of the mRNA results in the production of aberrant proteins. Metazoans efficiently clear readthrough proteins, but the underlying mechanisms remain unknown.
Martin B D Müller +3 more
semanticscholar +1 more source
Translation readthrough mitigation [PDF]
Nature, 2016 A fraction of ribosomes engaged in translation will fail to terminate when reaching a stop codon, yielding nascent proteins inappropriately extended on their C termini. Although such extended proteins can interfere with normal cellular processes, known mechanisms of translational surveillance are insufficient to protect cells from potential dominant ...
Arribere, Joshua A +6 more
openaire +4 more sources
Statistical analysis of readthrough levels for nonsense mutations in mammalian cells reveals a major determinant of response to gentamicin. [PDF]
PLoS Genetics, 2012 The efficiency of translation termination depends on the nature of the stop codon and the surrounding nucleotides. Some molecules, such as aminoglycoside antibiotics (gentamicin), decrease termination efficiency and are currently being evaluated for ...
Célia Floquet +3 more
doaj +1 more source
Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules
bioRxiv, 2023 Premature termination codons (PTCs) cause ∼10-20% of Mendelian diseases and are the major mechanism of tumor suppressor gene inactivation in cancer.
Ignasi Toledano, F. Supek, Ben Lehner
semanticscholar +1 more source