Results 41 to 50 of about 12,504 (200)
Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae.
PLoS Genetics, 2021 Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release.
Kotchaphorn Mangkalaphiban +5 more
doaj +1 more source
Pharmaceuticals, 2023 Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level.
Nesrine Benslimane +9 more
semanticscholar +1 more source
Genome-wide screening reveals metabolic regulation of stop-codon readthrough by cyclic AMP
Nucleic Acids Research, 2023 Translational fidelity is critical for microbial fitness, survival and stress responses. Much remains unknown about the genetic and environmental control of translational fidelity and its single-cell heterogeneity.
Zhihui Lyu +7 more
semanticscholar +1 more source
Transcriptional Readthrough Interrupts Boundary Function in Drosophila
International Journal of Molecular Sciences, 2023 In higher eukaryotes, distance enhancer-promoter interactions are organized by topologically associated domains, tethering elements, and chromatin insulators/boundaries. While insulators/boundaries play a central role in chromosome organization, the mechanisms regulating their functions are largely unknown.
Olga Kyrchanova +5 more
openaire +2 more sources
DoGFinder: a software for the discovery and quantification of readthrough transcripts from RNA-seq
BMC Genomics, 2018 Background Recent studies have described a widespread induction of transcriptional readthrough as a consequence of various stress conditions in mammalian cells.
Yuval Wiesel, Niv Sabath, Reut Shalgi
doaj +1 more source
International Journal of Molecular Sciences, 2023 Nonsense mutations trigger premature translation termination and often give rise to prevalent and rare genetic diseases. Consequently, the pharmacological suppression of an unscheduled stop codon represents an attractive treatment option and is of high ...
R. Wagner +5 more
semanticscholar +1 more source
Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain.
Brain : a journal of neurology, 2022 Alzheimer's disease is initiated by the toxic aggregation of amyloid-β. Immunotherapeutics aimed at reducing amyloid beta are in clinical trials but with very limited success to date.
D. Sapkota +9 more
semanticscholar +1 more source
PLoS ONE, 2019 Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to truncated p53 protein with impaired function.
Michael W Ferguson +9 more
doaj +1 more source
Frontiers in Oncology, 2018 The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional ...
Meiqiongzi Zhang +5 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequence ...
R. Perriera +11 more
semanticscholar +1 more source