Results 51 to 60 of about 12,543 (199)
Biomolecules, 2023 Premature termination codons (PTCs) account for ~12% of all human disease mutations. Translation readthrough-inducing drugs (TRIDs) are prominent among the several therapeutic approaches being used to overcome PTCs.
Mikel D. Ghelfi +3 more
doaj +1 more source
Features of readthrough genes.
, 2016 A: Scatterplot comparing readthrough and expression, including only those genes that passed the filters (see bioinformatics methods in supplementary information for description of filters).
Grzegorz Kudla (16996) +9 more
core +1 more source
Evidence of efficient stop codon readthrough in four mammalian genes [PDF]
, 2014 Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes had been reported.
Ming-yuan Chou +16 more
core +1 more source
Transcriptional Readthrough Interrupts Boundary Function in Drosophila
International Journal of Molecular Sciences, 2023 In higher eukaryotes, distance enhancer-promoter interactions are organized by topologically associated domains, tethering elements, and chromatin insulators/boundaries. While insulators/boundaries play a central role in chromosome organization, the mechanisms regulating their functions are largely unknown.
Olga Kyrchanova +5 more
openaire +2 more sources
Nonsense Suppression Therapy: An Emerging Treatment for Hereditary Skin Diseases
Acta Dermato-Venereologica, 2022 Nonsense mutations cause the premature termination of protein translation via premature termination codons (PTCs), leading to the synthesis of incomplete functional proteins and causing large numbers of genetic disorders.
Jiangfan Yu +5 more
doaj +1 more source
, 2013 Percentage Readthrough is 100 times the ratio of Firefly luminescence (downstream reporter) to Renilla luminescence (upstream reporter), divided by this ratio for the full readthrough strain.
Clara S. Chan (164398) +2 more
core +1 more source
Biological mechanisms and pharmacological inducibility of translational readthrough.
, 2021 Die Termination der Translation wird initiiert, wenn die A-Stelle des Ribosoms ein Stopcodon erreicht und Terminationsfaktoren mit dem Stopcodon interagieren.
Werfel, Lina Karen
core +1 more source
Frontiers in Oncology, 2018 The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional ...
Meiqiongzi Zhang +5 more
doaj +1 more source
Multiple Localization by Functional Translational Readthrough
, 2018 In a compartmentalized cell, correct protein localization is crucial for function of virtually all cellular processes. From the cytoplasm as a starting point, proteins are imported into organelles by specific targeting signals. Many proteins, however, act in more than one cellular compartment.
Bersch, Kristina +4 more
openaire +3 more sources
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source