Results 61 to 70 of about 12,543 (199)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

open access: yesCytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen   +3 more
wiley   +1 more source

Ribosomal frameshifting, jumping and readthrough

open access: yesCurrent Opinion in Cell Biology, 1991
New examples of high-level ribosomal frameshift and readthrough events have been described over the past year and a half. These include -1 frameshifting at tandem codons and +1 frameshifting at neighboring slow codons. Several bizarre examples of ribosome jumping and multiple stop-codon readthrough continue to perplex investigators in this field.
openaire   +2 more sources

Poly(A)-Binding Protein Regulates the Efficiency of Translation Termination

open access: yesCell Reports, 2020
Summary: Multiple factors influence translation termination efficiency, including nonsense codon identity and immediate context. To determine whether the relative position of a nonsense codon within an open reading frame (ORF) influences termination ...
Chan Wu   +4 more
doaj   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve   +5 more
wiley   +1 more source

Investigation of Novel RNA Elements in the 3′UTR of Tobacco Necrosis Virus-D

open access: yesViruses, 2020
RNA elements in the untranslated regions of plus-strand RNA viruses can control a variety of viral processes including translation, replication, packaging, and subgenomic mRNA production.
Laura R. Newburn   +2 more
doaj   +1 more source

Epidemiological drivers of turnip yellows virus and its vector Myzus persicae in Australian canola (Brassica napus) systems: a 3‐year study of commercial crops and noncrop vegetation

open access: yesPest Management Science, EarlyView.
A 3‐year study across southern Australia aimed to characterize drivers of infection in the Myzus persicae–turnip yellows virus–Brassica napus pathosystem. Identification of key reservoir hosts and the strong association between earlier sowing and increased disease incidence highlight opportunities for targeted weed management, strategic sowing ...
Samantha E Edley   +9 more
wiley   +1 more source

Molecular Analysis of Translational Readthrough in Tobacco necrosis virus-D [PDF]

open access: yes, 2021
Plus-sense single-stranded RNA plant viruses are a large group of agriculturally and economically important plant pathogens. These viruses encode their own RNA-dependent RNA polymerase (RdRp), whose translation from the viral genome is critical for a ...
Newburn, Laura Rachelle
core  

Full‐length transcriptome profiling of true bug mitochondrial genomes reveals the unique transcriptional regulation during insect evolution

open access: yesInsect Science, EarlyView.
The mitogenome was transcribed into complete primary polycistrons on both strands. The heteropteran mitochondrial transcription termination factor (HmTTF) functions as a bidirectional attenuator rather than a terminator, and co‐evolution of HmTTF and the binding sites was observed.
Shiwen Xu   +6 more
wiley   +1 more source

Readthrough-dependent loci.

open access: yes, 2012
A) Loci detected for each growth condition as significantly different between X-QTL allele frequencies in wildtype and sup35 selected pools (FDR 5%, Materials and Methods).
Leonid Kruglyak (4562)   +1 more
core   +1 more source

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong   +4 more
wiley   +1 more source

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