Results 61 to 70 of about 220,055 (304)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Energy Management Strategies for Extended-Range Electric Vehicles with Real Driving Emission Constraints

Applied Sciences
Fuel economy has long been the core control objective in the energy management strategies of extended-range electric vehicles (EREVs), but little research has considered real driving emissions.
Hualong Xu, Yang Chen, Li Zhang, Guoliang Chen, Jinlin Han, Qing Zhang, Chaokai Li   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

ParcEMon: IoT Platform for Real-Time Parcel Level Last-Mile Delivery Greenhouse Gas Emissions Reporting and Management

Sensors, 2022
Transport is Australia’s third-largest source of greenhouse gases accounting for around 17% of emissions. In recent times, and particularly as a result of the global pandemic, the rapid growth within the e-commerce sector has contributed to last-mile ...
Ali Yavari, Hamid Bagha, Harindu Korala, Irfan Mirza, Hussein Dia, Paul Scifleet, Jason Sargent, Mahnaz Shafiei   +7 more
doaj   +1 more source

Drive-style emission testing on the latest two Honda hybrid technologies [PDF]

, 2009
Introduction Hybrid technology is seen by many as a potential solution to reduce vehicle emissions in cities. However type approval tests of hybrid vehicles measure emission levels comparable to those of conventional cars in the same market segment.
ALESSANDRINI, Adriano, ORECCHINI, FABIO, ORTENZI, FERNANDO, VILLATICO CAMPBELL, Federico   +3 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Real Driving Range in Electric Vehicles: Influence on Fuel Consumption and Carbon Emissions

World Electric Vehicle Journal, 2021
This paper is focused on the determination of real driving ranges for electric vehicles (EV’s) and how it influences fuel consumption and carbon emissions. A precise method to evaluate the driving range of an EV can establish the correct reduction in GEI
Carlos Armenta-Déu, Erwan Cattin
doaj   +1 more source

Environmental assessment of low speed policies for motor vehicle mobility in city centres [PDF]

, 2011
streets in local residential areas in large cities, real traffic tests for pollutant emissions and fuel consumption have been carried out in Madrid city centre.
Casanova Kindelán, Jesús, Fonseca González, Natalia Elizabeth   +1 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Energy management strategies for hybrid diesel vehicles by dynamic planning embedded in real-world driving emission model

Case Studies in Thermal Engineering
The optimization of energy management strategy for hybrid vehicles is often based on engine steady performance data and the standard driving cycle conditions in the laboratory.
Yingzhang Wang, Li Zhang, Yang Chen, Chaokai Li, Baocheng Du, Jinlin Han   +5 more
doaj   +1 more source