Results 121 to 130 of about 585,502 (356)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Algumas notas sobre “realismo” e “ultrarealismo” em Sartre

open access: yesDoisPontos, 2006
This paper intends to research the possibility of thinking the several elements of Sartre's works according to one axe named "realism". It is important to explain what "realism" means here. Not intending find out a definition of "realism". Here "realism"
Alexandre de Oliveira Torres Carrasco
doaj  

Predicting Perceived Realism in Virtual Reality Driving Simulations Using Participants’ Personality Traits, Heart Rate Changes, and Risk Preference

open access: yesIEEE Access
Virtual reality (VR) has recently been adopted for driving simulations to enhance their realism and thus improve the validity of the simulation results. However, given that perceived realism is a subjective factor that varies by individual, understanding
Uijong Ju, Sanghyeon Kim
doaj   +1 more source

Realism and the language dependence of the external world : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Philosophy at Massey University [PDF]

open access: yes, 1985
This Thesis falls loosely into 2 Parts. In Part 1 (Chs. 1-4) a certain version of the view generally called "Realism" is put forward. This Realism is a view that can take either of two forms, one weak or soft, the other hard or strong.
Perrott, Richard John
core  

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

open access: yesFEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová   +11 more
wiley   +1 more source

Naive Realism for Unconscious Perceptions [PDF]

open access: yes
Unconscious perceptions (i.e., person-level perceptions that lack phenomenal character) have recently become a focal point in the debate for and against naive realism. In this paper I defend the naive realist side.
Beck, Ori
core  

Decoherent Histories and Realism [PDF]

open access: yes, 1999
We reconsider the Decoherent Histories approach to Quantum Mechanics and we analyze some problems related to its interpretation which, according to us, have not been adequately clarified by its proponents.
Bassi, Angelo, Ghirardi, GianCarlo
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao   +7 more
wiley   +1 more source

Establishment and optimization of the two‐step induction system for generating primordial germ cell‐like cells from chicken embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li   +10 more
wiley   +1 more source

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