Results 11 to 20 of about 32,034 (209)

Mapping the HPV Detection Landscape in Botswana: A Narrative Review of Diagnostic Platforms and Their Impact on Cervical Cancer Control. [PDF]

Health Sci Rep
ABSTRACT Background and Aim Cervical cancer is a major public health issue in Botswana, driven by high HIV prevalence and limited screening access. Molecular detection of high‐risk human papillomavirus (hrHPV) is crucial for prevention and early diagnosis.
Tawe L.
europepmc   +2 more sources

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents [PDF]

, 2014
Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes.
A Owsianka, A Sigal, Aleem Siddiqui, Arvind H. Patel, AS Lok, AW Tarr, B Bartolini, B Sainz Jr, C Hezode, C Lee, C Nathan, C Sarrazin, CL Brimacombe, CM Lange, CT Jones, D Masson, D Trono, EJ Gane, Eric Soulier, F Kuonen, F Poordad, F Poordad, Fei Xiao, François Habersetzer, G Koutsoudakis, H Kwon, H Yan, H Zhu, Heidi Barth, I Fofana, I Fofana, I Fofana, IA Abela, IM Jacobson, Isabel Fofana, J Grove, J Lupberger, J Witteveldt, J Zhong, Jens Bukh, JG McHutchison, JM Gottwein, JM Gottwein, JM Pawlotsky, JM Pawlotsky, JM Pawlotsky, JM Timpe, L Rong, L Zona, Laura Heydmann, LW Meredith, MB Zeisel, MB Zeisel, Michel Doffoël, Mirjam B. Zeisel, MN Zahid, MS Sulkowski, MT Catanese, N Shi, O Lenz, P Zhong, PM Trembling, Q Sattentau, S Haid, T Pietschmann, T Pietschmann, T Wakita, Thomas F. Baumert, TJ Liang, TK Scheel, V Soriano, VD Cataldo, ZY Keck   +72 more
core   +11 more sources

Development of approaches for studying the biodistribution of a bicistronic therapeutic plasmid construct in the mouse body

Фармакокинетика и Фармакодинамика, 2022
Relevance. The use of gene therapy drugs for the treatment of genetic diseases and stimulation of regeneration processes is lengthy and involves repeated injections, which may lead to increased dissemination of gene therapy constructs from the injection ...
S. S. Dzhauari, M. N. Karagyaur, V. Yu. Balabanyan, M. N. Skryabina, A. L. Primak, D. V. Stambolsky   +5 more
doaj   +1 more source

Improved detection of respiratory viruses in pediatric outpatients with acute respiratory illness by real-time PCR using nasopharyngeal flocked swabs [PDF]

, 1999
Detection of respiratory viruses by realtime multiplexed PCR (M-PCR) and of RSV by M-PCR and immunofluorescence(IF) was evaluated using specimens collected by nasopharyngeal flocked swab(NFS) and nasal wash(NW).
Munywoki, Patrick, Hamid, Fauzat, Mutunga, Martin, Welch, Steve, Cane, Patricia, Nokes, D. James   +5 more
core   +2 more sources

Comparison of Identification of Toxoplasma gondii by Commercial Realtime PCR and Inhouse Realtime PCR Methods

Middle Black Sea Journal of Health Science, 2019
Objective: This study aimed to compare the diagnosis of toxoplasmosis with a commercial kit and inhouse realtime PCR methods to determine molecular methods with high diagnostic accuracy for use in addition to serologic tests for routine diagnosis.Methods: The study included a total of 116 samples of blood, CSF or amniotic fluid with 19 identified ...
Selma USLUCA, Bekir ÇELEBİ
openaire   +3 more sources

The Abbott RealTime MTB assay and the Cepheid GeneXpert assay show comparable performance for the detection of Mycobacterium tuberculosis in sputum specimens

International Journal of Infectious Diseases, 2016
Objectives: To evaluate the performance of the newly developed technology Abbott RealTime MTB assay (RealTime MTB assay) for the detection of Mycobacterium tuberculosis in sputum specimens and to compare its performance with that of the Cepheid GeneXpert
Sheng Fen Wang, Xi Chao Ou, Qiang Li, Hui Wen Zheng, Yu Feng Wang, Yan Lin Zhao   +5 more
doaj   +1 more source

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Bachmann, Malte, Mühl, Heiko, Paulukat, Jens, Pfeilschifter, Josef Martin   +3 more
core   +1 more source

The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]

, 2018
Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella, Chiappetta, Caterina, Della Rocca, Carlo, Di Cristofano, Claudio, Petrozza, Vincenzo, Puggioni, Chiara   +5 more
core   +1 more source

RESULTS OF DETERMINING THE SPECIES COMPOSITION OF VAGINAL LACTOBACILLI USING REAL-TIME PCR TESTING AND BACTERIOLOGICAL METHOD

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. To compare the species composition of lactobacilli in women of reproductive age using real time PCR on urogenital samples before and after culturing microorganisms in Blood-Serum-Y^ast extract-Agar (BSYA). Materials and methods. Using real time PCR,
E. S. Voroshilina, D. L. Zornikov, L. G. Boronina   +2 more
doaj   +1 more source