Results 81 to 90 of about 692,148 (292)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Illusory Arguments by Artificial Agents: Pernicious Legacy of the Sophists
HumanitiesTo diagnose someone’s reasoning today as “sophistry” is to say that this reasoning is at once persuasive (at least to a significant degree) and logically invalid.
Micah H. Clark, Selmer Bringsjord
doaj +1 more source
Do we de-bias ourselves?: The impact of repeated presentation on the bat-and-ball problem
Judgment and Decision Making, 2019 The notorious bat-and-ball problem has long been used to demonstrate that people are easily biased by their intuitions. In this paper we test the robustness of biased responding by examining how it is affected by repeated problem presentation ...
Matthieu Raoelison, Wim De Neys
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
A proximity effect in adults’ contamination intuitions
Judgment and Decision Making, 2011 Magical beliefs about contagion via contact (Rozin, Nemeroff, Wane, & Sherrod, 1989) may emerge when people overgeneralize real-world mechanisms of contamination beyond their appropriate boundaries (Lindeman & Aarnio, 2007).
Laura R. Kim, Nancy S. Kim
doaj +1 more source
Sufficient Reason and Reason Enough [PDF]
Foundations of Science, 2015 I offer an analysis of the Principle of Sufficient Reason and its relevancy for the scientific endeavour. I submit that the world is not, and cannot be, rational - only some brained beings are. The Principle of Sufficient Reason is not a necessary truth nor a physical law.
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Study of the executive functions of reasoning, planning, organizing and working memory among the students with or without mathematics disorder at primary schools in Tehran province. [PDF]
Ravānshināsī-i Afrād-i Istis̠nāyī, 2012 Purpose: The present research’s purpose is to compare the executive functions of reasoning, planning, organizing and working memory between the students with or without mathematics disorder at primary school.
Mojdeh Janeh +2 more
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