Results 141 to 150 of about 2,499,352 (307)
Advocacy for looked after children and children in need: achievements and challenges [PDF]
, 2006 This briefing paper offers a summary of the key findings of ‘Advocacy for looked after children and children in need: achievements and challenges’, the first national study of children’s advocacy in England.
Candappa, Mano +2 more
core
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Les Cahiers d’EMAMThe political and territorial fragmentation of Iraq is at the origin of territorial oddities. Some parts of Iraqi territory are controlled by armed non-State actors (militias) supported by tutelary powers, usually competitors.
Cyril Roussel
doaj
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Working Paper 73 - Economic and Political Causes of Civil Wars in Africa: Some Econometric Results [PDF]
In this paper, we investigated whether civil wars in Africa have economic andpolitical causes. The model is based on the Collier-Hoeffler “greed” and “grievance”theory in which rebels will conduct a civil war for “loot-seeking” and “justiceseeking ...
John Anyanwu
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Opposable reasons: solving conflicts of fundamental rights and norms
, 2021 This dissertation argues that the deadlock that constitutional courts find themselves in when justifying decisions on cases that involve conflicting constitutional norms can be best resolved by appealing to a particular type of reasons, namely opposable reasons.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source