Results 1 to 10 of about 2,128 (154)

Two Decades of Advances and Limitations in Organ Recellularization [PDF]

Current Issues in Molecular Biology
The recellularization of tissues after decellularization is a relatively new technology in the field of tissue engineering (TE). Decellularization involves removing cells from a tissue or organ, leaving only the extracellular matrix (ECM).
Alina Stoian, Aisha Adil, Felor Biniazan, Siba Haykal   +3 more
doaj   +5 more sources

Bioengineering of vascularized porcine flaps using perfusion-recellularization [PDF]

Scientific Reports
Large volume soft tissue defects greatly impact patient quality of life and function while suitable repair options remain a challenge in reconstructive surgery.
Michael S. Xu, Andrew D’Elia, Nina Hadzimustafic, Aisha Adil, Golnaz Karoubi, Thomas K. Waddell, Siba Haykal   +6 more
doaj   +4 more sources

Recellularization of Bioengineered Scaffolds for Vascular Composite Allotransplantation

Frontiers in Surgery, 2022
Traumatic injuries or cancer resection resulting in large volumetric soft tissue loss requires surgical reconstruction. Vascular composite allotransplantation (VCA) is an emerging reconstructive option that transfers multiple, complex tissues as a whole ...
Aisha Adil, Aisha Adil, Michael Xu, Michael Xu, Michael Xu, Siba Haykal, Siba Haykal, Siba Haykal   +7 more
doaj   +3 more sources

Decellularization and Recellularization Technologies in Tissue Engineering

Cell Transplantation, 2014
Decellularization is the process by which cells are discharged from tissues/organs, but all of the essential cues for cell preservation and homeostasis are retained in a three-dimensional structure of the organ and its extracellular matrix components ...
Ru-Huei Fu Ph.D., Yu-Chi Wang, Shih-Ping Liu, Ton-Ru Shih, Hsin-Lien Lin, Yue-Mi Chen, Jiun-Huei Sung, Chia-Hui Lu, Jing-Rong Wei, Zih-Wan Wang, Shyh-Jer Huang, Chang-Hai Tsai, Woei-Cherng Shyu, Shinn-Zong Lin M.D., Ph.D.   +13 more
doaj   +3 more sources

Ex vivo perfusion recellularization of acellular rat hindlimbs for vascular composite allotransplantation [PDF]

Scientific Reports
Vascular composite allotransplantation (VCA) is a promising reconstructive surgical option for severe tissue loss. Autologous reconstructive methods are limited by donor tissue availability and donor site morbidity.
Aisha Adil, Felor Biniazan, Valentina Shamoun, Golnaz Karoubi, Siba Haykal   +4 more
doaj   +2 more sources

A Review on Bioengineering the Bovine Mammary Gland: The Role of the Extracellular Matrix and Reconstruction Prospects [PDF]

Bioengineering
The mammary gland is a modified sweat gland responsible for milk production. It is affected by diseases that reduce animals’ quality of life, consequently leading to economic losses in livestock.
Fernando Chissico Júnior, Thamires Santos da Silva, Flávio Vieira Meirelles, Paulo Sérgio Monzani, Lucas Fornari Laurindo, Sandra Maria Barbalho, Maria Angélica Miglino   +6 more
doaj   +2 more sources

Development of a 3D tumor model based on decellularized matrix using high-throughput approaches [PDF]

Frontiers in Bioengineering and Biotechnology
Precision medicine aims to develop 3D tumor models to validate new therapies and investigate disease mechanisms by isolating the extracellular matrix as a foundation for recreating tumors in vitro.
Homayoon Siahmansouri, Daniela Fenoglio, Daniela Fenoglio, Gilberto Filaci, Gilberto Filaci, Maddalena Mastrogiacomo, Maddalena Mastrogiacomo   +6 more
doaj   +2 more sources

Evaluating different methods for kidney recellularization. [PDF]

Sci Rep
Abstract This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation is the best option, but there aren't enough organs available. The researchers used tissue engineering to evaluate the possibility for creating kidneys for transplantation.
Luque-Badillo AC, Monjaras-Avila CU, Adomat H, So A, Chavez-Muñoz C.   +4 more
europepmc   +4 more sources

Decellularization techniques: unveiling the blueprint for tracheal tissue engineering [PDF]

Frontiers in Bioengineering and Biotechnology
Certain congenital or acquired diseases and defects such as tracheo-oesophageal fistula, tracheomalacia, tracheal stenosis, airway ischemia, infections, and tumours can cause damage to the trachea.
Keisha T. Gomes, Palla Ranga Prasad, Jagnoor Singh Sandhu, Jagnoor Singh Sandhu, Ashwini Kumar, Naveena A. N. Kumar, N. B. Shridhar, Bharti Bisht, Manash K. Paul, Manash K. Paul   +9 more
doaj   +2 more sources

A New Method for Preparation of Decellularized Human Scaffolds for Facial Reconstruction [PDF]

Current Issues in Molecular Biology
Vascularized composite allotransplantation (VCA) has emerged as a robust alternative for addressing anatomically complex defects but requires a toxic lifelong immunosuppressive regimen. Tissue engineering offers the promise of creating recipient-specific
Elise Lupon, Aylin Acun, Alec R. Andrews, Ruben Oganesyan, Hyshem H. Lancia, Laurent Lantieri, Mark A. Randolph, Curtis L. Cetrulo, Alexandre G. Lellouch, Basak E. Uygun   +9 more
doaj   +2 more sources