Results 91 to 100 of about 119,693 (290)
A2B Adenosine Receptor and Cancer
International Journal of Molecular Sciences, 2019 There are four subtypes of adenosine receptors (ARs), named A1, A2A, A2B and A3, all of which are G protein-coupled receptors (GPCRs). Locally produced adenosine is a suppressant in anti-tumor immune surveillance. The A2BAR, coupled to both Gαs and Gαi G
Zhang-Guo Gao, K. Jacobson
semanticscholar +1 more source
Functional selectivity of adenosine A1 receptor ligands? [PDF]
Purinergic Signalling, 2012 The concept of functional selectivity offers great potential for the development of drugs that selectively activate a specific intracellular signaling pathway. During the last few years, it has become possible to systematically analyse compound libraries on G protein-coupled receptors (GPCRs) for this 'biased' form of signaling.
Ellen V, Langemeijer +3 more
openaire +2 more sources
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Molecular Pain, 2010 BackgroundEcto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits.
Nathaniel A. Sowa +2 more
semanticscholar +1 more source
International Journal of Cancer, EarlyView.What's New? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song +10 more
wiley +1 more source
Journal of Pharmacological Sciences, 2023 This study investigated whether the repeated topical paeoniflorin inhibits postoperative pain in mice. An incision of the plantar skin and underlying muscle of the hind paw elicits acute postoperative pain.
Tsugunobu Andoh, Momoka Goto
doaj
Balkan Medical Journal, 2015 Background: Citalopram is a selective serotonin reuptake inhibitor that requires routine cardiac monitoring to prevent a toxic dose. Prolongation of the QT interval has been observed in acute citalopram poisoning.
Müjgan Büyükdeligöz +4 more
doaj +1 more source
Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine. [PDF]
PLoS ONE, 2015 Despite considerable evidence that glia can release modulators to influence the excitability of neighbouring neurons, the importance of gliotransmission for the operation of neural networks and in shaping behaviour remains controversial.
David Acton, Gareth B Miles
doaj +1 more source
iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Allosteric modulation of adenosine receptors [PDF]
, 2008 Allosteric modulators for adenosine receptors may have potential therapeutic advantage over orthosteric ligands. Allosteric enhancers at the adenosine A1 receptor have been linked to antiarrhythmic and antilipolytic activity.
Göblyös, Anikó, IJzerman, Ad P.
core +2 more sources