Results 101 to 110 of about 119,693 (290)

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Nature, 2021
C. Draper-Joyce, Rebecca F. Bhola, Jinan Wang, A. Bhattarai, A. T. Nguyen, India Cowie-Kent, Kelly O’Sullivan, Ling Yeong Chia, H. Venugopal, C. Valant, D. Thal, D. Wootten, Nicolas Panel, Jens Carlsson, M. Christie, P. White, P. Scammells, L. May, P. Sexton, R. Danev, Yinglong Miao, A. Glukhova, Wendy L. Imlach, A. Christopoulos   +23 more
semanticscholar   +1 more source

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands

British Journal of Pharmacology, 2010
Background and purpose:  The introduction of fluorescence‐based techniques, and in particular the development of fluorescent ligands, has allowed the study of G protein‐coupled receptor pharmacology at the single cell and single molecule level.
J. Baker, R. Middleton, Luke A. Adams, L. May, S. Briddon, B. Kellam, Stephen J Hill   +6 more
semanticscholar   +1 more source

Treatment Selection and Prioritization for the EJS ACT‐PD MAMS Trial Platform

Movement Disorders, EarlyView.
Abstract Background There are currently no disease‐modifying therapies (DMTs) registered for Parkinson's disease (PD). The Edmond J. Safra Accelerating Clinical Trials in Parkinson Disease (EJS ACT‐PD) initiative will expedite clinical assessment of putative DMTs through a multi‐arm multistage (MAMS) trial, testing several treatments against a common ...
Cristina Gonzalez‐Robles, Dilan Athauda, Thomas R. Barber, Roger A. Barker, David T. Dexter, Susan Duty, Romy Ellis‐Doyle, Sonia Gandhi, Joel Handley, Edwin Jabbari, Keith Martin, Kevin McFarthing, Georgia Mills, Heather Mortiboys, Stephen Mullin, Rebecca Petty, Esther Sammler, Paula Scurfield, Simon R.W. Stott, George K. Tofaris, Li Wei, Caroline H. Williams‐Gray, Alan Wong, Marie‐Louise Zeissler, Richard K. Wyse, Camille B. Carroll, Thomas Foltynie, Oliver Bandmann, Anthony H.V. Schapira, on behalf of the EJS ACT‐PD Consortium   +29 more
wiley   +1 more source

Protective effect of Adenosine A1 receptor and ascorbic acid on hippocampal neuronal density and memory disorder in ischemia reperfusion induced Rats

مجله دانشگاه علوم پزشکی گرگان, 2012
Background and Objective: Brain ischemia is one of the most important factor of morbidity and mortality and leaving many people with mental and physical disabilities.
Zamani M (MSc), Rasooli H (PhD), Mehdizadeh M (PhD), Nobakht M (PhD), Zamani F (BSc), Soleimani M (PhD)   +5 more
doaj  

Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus [PDF]

, 2007
Adenosine and ATP, via their specific P1 and P2 receptors, modulate a wide variety of cellular and tissue functions, playing a neuroprotective or neurodegenerative role in brain damage conditions. Although, in general, adenosine inhibits excitability and
Amadio, Anderson, Bachevalier, Benvensiste, Bergersen, Bergersen, Bezzi, Blum, Braun, Burnstock, C. Martini, Chaudhry, Choi, Ciruela, Ciruela, Cordeaux, Cotman, Cunha, Dixon, Duarte, Dunwiddie, Franke, Franke, Franke, Franke, Franke, Fredholm, Fredholm, Fredholm, Fumagalli, Gao, Giuntini, Gottlieb, Gundersen, Gundersen, Gylterud Owe, Hagberg, Harry, Hoffmann, Hollopeter, Hourani, I. Tonazzini, J. Storm-Mathisen, Jimenez, Jourdain, Kawamura, Koizumi, L. H. Bergersen, Lasley, Lopes, Lorenzen, Lorenzen, M. L. Trincavelli, Maemoto, Masino, Mendoza-Fernandez, Moore, Moore, Moran-Jimenez, Moro, Munshi, Murphy, Nagelhus, Nakata, Neary, Newman, Niebauer, Ochiishi, Ottersen, Palmer, Piper, Ponzio, Rathbone, Rebola, Rebola, Rodrigues, Rudolphi, Sasaki, Swanson, Trincavelli, Vohringer, Volonté, Von Kugelgen, Waldo, Wang, Wang, Wardas, Yoshioka, Yoshioka, Yoshioka, Zhang, Zhu, Zimmermann   +92 more
core   +2 more sources

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis

Molecular Nutrition &Food Research, EarlyView.
Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés, Andreu Gual‐Grau, Juan Vicente Sancho, Maria P. Portillo   +5 more
wiley   +1 more source

Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries

Journal of Pharmacological Sciences, 2013
In hypertension, vascular reactivity alterations have been attributed to numerous factors, including higher sympathetic innervation/adenosine. This study examined the modulation of adenosine receptors on vascular sympathetic nerves and their putative ...
Carolina Rocha-Pereira, Silvia Magdalena Arribas, Paula Fresco, Maria Carmen González, Jorge Gonçalves, Carmen Diniz   +5 more
doaj  

Regionally resolved cardiac metabolism using a dipole‐loop array coil for 7 T 31P‐MRSI

Magnetic Resonance in Medicine, EarlyView.
Abstract Purpose We introduce a novel commercial phosphorus‐31 (31P) dipole‐loop array coil, describing the coil hardware and testing its performance on phantoms. We used this coil to assess cardiac metabolism per region in healthy volunteers. Methods B1+ field maps were simulated and compared to maps measured with a set of CSI sequences with varying ...
Jabrane Karkouri, Will Watson, Ria Forner, Jonathan R. Weir‐McCall, Tracy Horn, Marion Hill, Stephen Hoole, Dennis Klomp, Christopher T. Rodgers   +8 more
wiley   +1 more source

Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms

Frontiers in Pharmacology
Purinergic signaling has been implicated in many biological functions, including development. In this study, we investigate the functions of extracellular adenosine and adenosine receptors using a mouse embryonic stem cell (ESC) line and morula stages ...
Talita Glaser, Patrícia Martins, Renata Beco, Carolina Adriane Bento, Angelica R. Cappellari, Sophia La Banca Oliveira, Christian Albert Merkel, Vanessa Fernandes Arnaud-Sampaio, Claudiana Lameu, Ana Maria Battastini, Henning Ulrich   +10 more
doaj   +1 more source

Lack of endogenous adenosine tonus on sympathetic neurotransmission in spontaneously hypertensive rat mesenteric artery.

PLoS ONE, 2014
BackgroundIncreased sympathetic activity has been implicated in hypertension. Adenosine has been shown to play a role in blood flow regulation. In the present study, the endogenous adenosine neuromodulatory role, in mesenteric arteries from normotensive ...
Joana Beatriz Sousa, Maria Sofia Vieira-Rocha, Carlos Sá, Fátima Ferreirinha, Paulo Correia-de-Sá, Paula Fresco, Carmen Diniz   +6 more
doaj   +1 more source