Results 141 to 150 of about 119,693 (290)
Journal of Pharmacological Sciences, 2007 In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261,
Takahiro Matsuya +10 more
doaj
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel +11 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 7, Page 1558-1572, April 2025.Breast cancer is a complex disease significantly influenced by estrogen receptors (ERs) and the extracellular matrix (ECM), both of which are critical in shaping tumor behavior. ERα and ERβ modulate cancer progression and therapeutic response with their interactions intricately linked to ECM dynamics.
Sylvia Mangani +4 more
wiley +1 more source
Involvement of adenosine A1 receptors in systemic inflammation and altered vascular reactivity in allergic mice [PDF]
, 2008 Epidemiological studies have established that people who have lung diseases such as asthma and COPD are likely to develop adverse cardiovascular events. While the reason for this has not been elucidated, it is believed that inflammation could be the key ...
Ponnoth, Dovenia S.
core +1 more source
Structure and function of adenosine receptor heteromers
Cellular and Molecular Life Sciences, 2021 R. Franco +6 more
semanticscholar +1 more source
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source
Design and synthesis of new fluorescent probes for A2B adenosine receptor. [PDF]
, 2014 Adenosine is an endogenous purine nucleoside that plays a key role in numerous important physiological functions through interactions with specific cell-surface G-protein-coupled receptors (GPCRs), which are classified into four subtypes, namely A1, A2A,
MORETTI, ELEONORA
core
The FEBS Journal, EarlyView.Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun +5 more
wiley +1 more source
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, EarlyView.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
The FEBS Journal, EarlyView.In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman +13 more
wiley +1 more source