Results 181 to 190 of about 119,693 (290)

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenine Nucleotide-Sensitive Adenosine Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors (A1R) are able to form a heteromeric complex with P2Y1 receptors (P2Y1R) that generates A1R with P2Y1R-like agonistic pharmacology.
Kazuaki Yoshioka, Hiroyasu Nakata
doaj  

Evidence for control of cerebral neurovascular function by circulating platelets in healthy older adults

The Journal of Physiology, EarlyView.
Abstract figure legend Epidemiological evidence suggests a link between dementia and cardiovascular health, including the regulation of platelets. To investigate this relationship, we examined how platelet reactivity relates to cerebral neurovascular function and systemic vascular reactivity in healthy older adults.
Gabriella M. K. Rossetti, Joanne L. Dunster, Aamir Sohail, Brendan Williams, Kiera M. Cox, Suzannah Rawlings, Elysia Jewett, Eleanor Benford, Julie A. Lovegrove, Jonathan M. Gibbins, Anastasia Christakou   +10 more
wiley   +1 more source

Regulation of Arousal by Adenosine A1 and A2A Receptors in the Prefrontal Cortex of C57BL/6J Mouse. [PDF]

Adenosine levels in the basal forebrain and cortex increase with prolonged wakefulness to promote sleep. Caffeine increases wakefulness by blocking adenosine receptors, yet the neurotransmitter systems and brain regions through which adenosine receptor ...
Van Dort, Christa J.
core  

Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-Sided Intramural Optical Mapping

Circulation, 2014
Q. Lou, Brian J. Hansen, O. Fedorenko, Thomas A. Csepe, A. Kalyanasundaram, Ning Li, Lori T. Hage, A. Glukhov, G. Billman, R. Weiss, P. Mohler, S. Györke, B. Biesiadecki, C. Carnes, V. Fedorov   +14 more
semanticscholar   +1 more source

Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application. [PDF]

Am J Transl Res
Solanki N, Dodiya R, Vejpara D, Azad S, Patel M, Patel S, Shah U, Soni A, Maheshwari R, Navale A, Patel A, Patel S, Sheth D, Tirgar P, R R.   +14 more
europepmc   +1 more source

Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory

Neuropsychopharmacology, 2011
V. Sousa, N. Assaife-Lopes, J. Ribeiro, J. Pratt, R. Brett, A. Sebastião   +5 more
semanticscholar   +1 more source

Prediction of 90 day mortality in elderly patients with acute HF from e‐health records using artificial intelligence

ESC Heart Failure, Volume 12, Issue 3, Page 2200-2209, June 2025.
Abstract Aims Mortality risk after hospitalization for heart failure (HF) is high, especially in the first 90 days. This study aimed to construct a model automatically predicting 90 day post‐discharge mortality using electronic health record (EHR) data 48 h after admission and artificial intelligence. Methods All HF‐related admissions from 2015 to 2020
Joconde Weller, Johann Gutton, Guillaume Hocquet, Leïla Pellet, Marie‐José Aroulanda, Amélie Bruandet, Didier Theis, Fabio Boudis, Romain Cador, Pierre Zweigenbaum, Anne Buronfosse, Pascal de Groote, Michel Komajda   +12 more
wiley   +1 more source

Fructose-1,6-Bisphosphate Reduces Chronic Constriction Injury Neuropathic Pain in Mice by Targeting Dorsal Root Ganglia Nociceptive Neuron Activation. [PDF]

Pharmaceuticals (Basel)
Dionisio AM, Milanez PAO, Zarpelon-Schutz AC, Mizokami SS, Bertozzi MM, Yaekashi KM, Camilios-Neto D, Borghi SM, Casagrande R, Verri WA.   +9 more
europepmc   +1 more source

Systemic EP4 receptor agonist and Arginase‐1 therapy in a murine model of chronic asthma and influenza virus‐induced asthma exacerbation

British Journal of Pharmacology, Volume 182, Issue 12, Page 2803-2820, June 2025.
Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange, Tobias Brunn, Charlotte Vetter, Konstantin Bloch, Nora Vedder, Chiel van Geffen, Philipp Gercke, Saeed Kolahian   +7 more
wiley   +1 more source

Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress. [PDF]

Cureus
Abdelmissih S, Ahmed Rashed L, Sharif Ismail Negm M, Mohamed Sayed W, Mahmoud HM, Elmorsy S.   +5 more
europepmc   +1 more source