Results 191 to 200 of about 1,574,412 (235)

Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular <i>Brucella</i> infection. [PDF]

mBio
Kang Y-S, Kirby JE.
europepmc   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

The ability of SABRE, a new quantitative receptor function model, to quantify receptor binding from even challenging concentration-effect data with a single unified fit. [PDF]

Front Pharmacol
Olah B, Tarjanyi V, Viczjan G, Ovari I, Csoto A, Szilvassy Z, Juhasz B, Zsuga J, Gesztelyi R, Erdei T.   +9 more
europepmc   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, Volume 604, Issue 17, Page 7313-7336, 1 September 2026.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

Impaired adenosine pathways in HFpEF: insights into cardiorenal alterations and endothelial responses. [PDF]

Front Pharmacol
Riemma MA, Madonna G, Mele E, Conte E, Telesca M, De Palma G, Kutryb-Zając B, Cicala C, Imbrici P, Liantonio A, De Angelis A, Urbanek K, Berrino L, Ialenti A, Cappetta D, Donniacuo M, Caiazzo E.   +16 more
europepmc   +1 more source

Heart failure‐induced reprogramming of salt‐evoked neurovascular coupling in the rat hypothalamus

The Journal of Physiology, Volume 604, Issue 18, Page 7845-7868, 15 September 2026.
Abstract figure legend In sham rat, hypertonic saline induces activation of the AVP neurons, leading to dendritic AVP release and subsequent V1aR‐mediated PA vasoconstriction resulting in local tissue hypoxia in the SON. In heart failure rat, hypertonic saline similarly induces activation of the AVP neuron leading to dendritic AVP release.
Ranjan K. Roy, Elba Campos Lira, Manuel Bita Ongolo, Jessica A. Filosa, Javier E. Stern   +4 more
wiley   +1 more source

Adenosine A2A receptor signaling in neuroinflammation, glial modulation, and mechanisms associated with chronic pain. [PDF]

Purinergic Signal
Barros CA, Rangel JG, de Oliveira Cruz B, De Araújo LP, Galdino G.   +4 more
europepmc   +1 more source

Hypnotic Effects of <i>Hypericum perforatum</i> L. and <i>Melissa officinalis</i> L. Through Adenosine and Melatonin Receptors. [PDF]

Nutrients
Jee HJ, Lee SJ, Yoo JR, Kim HJ, Park HS, See HJ, Jung YS.   +6 more
europepmc   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury. [PDF]

CNS Neurosci Ther
Zhu S, Zhong S, Lin X, Zhao C, Li Y.
europepmc   +1 more source

Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility. [PDF]

Proc Natl Acad Sci U S A
Xiao Y, Louwies T, Mars RAT, Till LM, Gupta Y, Mercado-Perez A, Bhagwate AV, Bellampalli SS, Stark Quiroz A, Sekhon PK, Singh V, Liu R, Heitman LH, Tienter D, Thompson MA, Kossick KF, Krueger EW, Kalari KR, Hawkins KR, Lee JH, Edwards BS, van der Es D, Alcaino C, Willett JLE, Wongkrasant P, Guo CJ, Prakash YS, Druliner BR, Ordog T, Farrugia G, Beyder A, Smith-Edwards KM, Kashyap PC.   +32 more
europepmc   +1 more source