Results 31 to 40 of about 119,693 (290)

Degranulation of rat omental mast cells by A1 receptor agonists in vitro

Mediators of Inflammation, 1996
The haemodynamic effects of adenosine are thought to result in part from a release of mast cell amines via A3 receptor stimulation. To investigate the nature of the receptors involved in adenosine-induced mast cell degranulation in the rat isolated ...
A. M. Northover, B. J. Northover
doaj   +1 more source

A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: a role in cell survival [PDF]

, 2016
The regulation of tissue transglutaminase (TG2) activity by the GPCR family is poorly understood. In this study, we investigated the modulation of TG2 activity by the A1 adenosine receptor in cardiomyocyte-like H9c2 cells.H9c2 cells were lysed following ...
Akar, Alan J. Hargreaves, Almami, Basheer, Bennett, Bian, Bollag, Brust, Caccamo, Calmettes, Clare Coveney, Csósz, Dai, David J. Boocock, Davies, Davies, Di-Capua, Dickenson, Dickenson, Dickenson, Dickenson, Dudley, Ethier, Falguni S. Vyas, Filiano, Fretwell, Freund, Germack, Germack, Germack, Germack, Goldsmith, Gundemir, Gundlfinger, Halestrap, Henry, Hescheler, Hoffert, Huang, Imami, John M. Dickenson, Keinan, Kettenbach, Kimes, Lambert, Lee, Lilley, Lorand, Lundby, Matilla, Mhaouty-Kodja, Min, Mishra, Mishra, Mosmann, Nurminskaya, Palacios-Moreno, Perry, Philip L.R. Bonner, Piacentini, Rikova, Robinson, Sabourin, Schaertl, Seshacharyulu, Sheth, Singh, Slaughter, Smith, Stamnaes, Trigwell, Walther, Wang, White, Xu, Yang, Yu, Zhang   +77 more
core   +1 more source

Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia

Scientific Reports, 2018
Acupuncture is one of the most promising modalities in complimentary medicine. However, the underlying mechanisms are not well understood yet. We found that in TRPV2 knockout male mice, acupuncture-induced analgesia was suppressed with a decreased ...
Meng Huang, Xuezhi Wang, Beibei Xing, Hongwei Yang, Z. Sa, Di Zhang, Wei Yao, Na Yin, Ying Xia, Guanghong Ding   +9 more
semanticscholar   +1 more source

Adenosine induces mesangial cell contraction by an A1-type receptor [PDF]

, 1989
Adenosine induces mesangial cell contraction by an A1-type receptor. Adenosine is known to decrease renal blood flow and glomerular filtration rate. We have tested the hypothesis that adenosine exerts contractile effects on mesangial cells.
Lamas, Santiago, López-Novoa, José M., Olivera, Ana, Rodriguez-Puyol, Diego   +3 more
core   +1 more source

A Role for Adenosine A1 Receptors in GABA and NMDA-Receptor Mediated Modulation of Dopamine Release: Studies Using Fast Cyclic Voltammetry

Sensors, 2008
In the striatum many neurotransmitters including GABA, glutamate, acetylcholine, dopamine, nitric oxide and adenosine interact to regulate synaptic transmission. Dopamine release in the striatum is regulated by a number of pre- and postsynaptic receptors
Carmel O’Neill, John J. O’Connor   +1 more
doaj   +1 more source

Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [103]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors).
Fredholm, Bertil B., Frenguelli, Bruno G., Hills, Rebecca, IJzerman, Adriaan P., Jacobson, Kenneth A., Klotz, Karl-Norbert, Linden, Joel, Müller, Christa E., Schwabe, Ulrich, Stiles, Gary L.   +9 more
core   +2 more sources

A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway

Molecular Brain, 2016
BackgroundThis study was designed to determine the role of the A1 adenosine receptors in intracerebral hemorrhage (ICH)-induced secondary brain injury and the underlying mechanisms.MethodsA collagenase-induced ICH model was established in Sprague–Dawley ...
Weiwei Zhai, Dongdong Chen, Haitao Shen, Zhouqing Chen, Haiying Li, Zhengquan Yu, Gang Chen   +6 more
semanticscholar   +1 more source

Probe dependence of allosteric enhancers on the binding affinity of adenosine A1‐receptor agonists at rat and human A1‐receptors measured using NanoBRET [PDF]

, 2019
Background and Purpose: Adenosine is a local mediator that regulates a number of physiological and pathological processes via activation of adenosine A1‐receptors.
Cooper, Samantha L., Hill, Stephen J., Jörg, Manuela, Scammells, Peter J., Soave, Mark, Woolard, Jeanette   +5 more
core   +2 more sources

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Molecules, 2011
The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or ...
Michal Hofer, Milan Pospisil, Zuzana Hoferova, Lenka Weiterova   +3 more
doaj   +1 more source

Involvement of adenosine signaling pathway in migraine pathophysiology: a systematic review of preclinical studies

The Journal of Headache and Pain, 2022
Background Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist ...
Janu Thuraiaiyah, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Messoud Ashina   +3 more
doaj   +1 more source