Results 11 to 20 of about 1,637,046 (206)

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2018
It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz, Natalie Rotermund, Katarzyna Grzelka, Jan Benz, Christian Lohr, Daniela Hirnet   +5 more
doaj   +2 more sources

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor [PDF]

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +2 more sources

Allosteric modulators for the A1 adenosine receptor

Expert Opinion on Therapeutic Patents, 2004
A review. Allosteric modulators of endogenous adenosine represent an alternative to direct acting adenosine agonists and nucleoside uptake blockers. These compds. can selectively enhance the response to adenosine in only those organs or localized areas of a given organ in which prodn. of adenosine is increased. The present article is an overview of the
BARALDI, Pier Giovanni, MOORMAN ALLAN R., AGHAZADEH TABRIZI, Mojgan, PAVANI, Maria Giovanna, ROMAGNOLI, Romeo   +4 more
openaire   +3 more sources

ALLOSTERIC MODULATORS OF THE A1 ADENOSINE RECEPTOR

, 2008
Title compd. I [R1 = H, (un)substituted alkyl, aryl or cycloalkyl; R2, R3 and R4 independently = H, halo, OH, NO2, CN, (un)substituted alkyl, aryl, cycloalkyl or alkoxy; Q = (un)substituted piperidinyl, azepinyl, 5-membered spirocyclic ring, etc.], and ...
BARALDI PIER GIOVANNI, MOORMAN ALLAN R, ROMAGNOLI ROMEO   +2 more
openaire   +4 more sources

ADENOSINE A1 RECEPTOR AGONISTS

, 1999
Preparation of deoxyfluoro nucleosides as adenosine A1 ...
COUSINS RICHARD PETER CHARLES, COX BRIAN, ELDRED COLIN DAVID, PENNELL ANDREW MICHAEL KENNETH   +3 more
core   +7 more sources

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Multisite Model of Allosterism for the Adenosine A1 Receptor [PDF]

Journal of Chemical Information and Modeling, 2020
ABSTRACT Despite being a target for about one-third of approved drugs, G protein-coupled receptors (GPCRs) still represent a tremendous reservoir for therapeutic strategies against countless diseases. For example, several cardiovascular and central nervous systems conditions could benefit from clinical agents that ...
Giuseppe Deganutti, Kerry Barkan, Graham Ladds, Christopher A. Reynolds   +3 more
openaire   +2 more sources

Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially Through the Adenosine A1 Receptor

Natural Product Communications, 2022
Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in an animal model.
Kazuya Kusama, Takumi Suzuki, Ryosuke Motohashi, Takumi Nobusawa, Koichiro Ota, Mana Azumi, Mikihiro Yoshie, Hiroaki Miyaoka, Kazuhiro Tamura   +8 more
doaj   +1 more source

A genetic variation in the adenosine A2A receptor gene contributes to variability in oscillatory alpha power in wake and sleep EEG and A1 adenosine receptor availability in the human brain

NeuroImage, 2023
The EEG alpha rhythm (∼ 8–13 Hz) is one of the most salient human brain activity rhythms, modulated by the level of attention and vigilance and related to cerebral energy metabolism.
Naemi L. Tichelman, Anna L. Foerges, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Andreas Bauer, Hans-Peter Landolt, Daniel Aeschbach, David Elmenhorst   +12 more
doaj   +1 more source

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]

Journal of Histochemistry & Cytochemistry, 2000
The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
MINELLI, Alba, ALLEGRUCCI, Cinzia, Piomboni P., MANNUCCI, Roberta, Lluis C., Franco R.   +5 more
openaire   +4 more sources