Results 31 to 40 of about 1,574,412 (235)
The Journal of Headache and Pain, 2018 Background Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels ...
Kristian A. Haanes +10 more
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Dual acting antioxidant A1 adenosine receptor agonists [PDF]
, 2007 Herein we report the synthesis and biological evaluation of some potent and selective A1 adenosine receptor agonists, which incorporate a functionalised linker attached to an antioxidant moiety.
Figler, Heidi +8 more
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陆军军医大学学报Objective To explore the expression profile of adenosine A1 receptor in the paraventricular thalamic nucleus (PVT) in wakefulness/sleep state and its role in regulating sleep.
ZHU Yifeng, WANG Na, HU Junya
doaj +1 more source
Journal of Pharmacological Sciences, 2005 The aim of the present study is to clarify the mechanism for the decrease in intraocular pressure by 2-alkynyladenosine derivatives in rabbits. The receptor binding analysis revealed that 2-(1-octyn-1-yl)adenosine (2-O-Ado) and 2-(6-cyano-1-hexyn-1-yl ...
Takashi Konno +5 more
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Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase : an in vitro rat study [PDF]
, 2014 In the brain, extracellular adenosine increases as a result of neuronal activity. The mechanisms by which this occurs are only incompletely understood. Here we investigate the hypothesis that the Na+ influxes associated with neuronal signalling activate ...
Sims, Robert E. +6 more
core +2 more sources
On the basis of sex: male vs. female rat adenosine A1/A2A receptor affinity
BMC Research Notes, 2023 Objective To ensure reproducibility in biomedical research, the biological variable sex must be reported; yet a reason for using male (instead of female) rodents is seldom given.
Helena D. Janse van Rensburg +2 more
doaj +1 more source
The role of the large conductance Ca2+-activated K+ channel in adenosine receptor-mediated cytoprotection [PDF]
, 2009 The rat embryonic cardiomyoblast-derived H9c2 cell line is increasingly used for studies into cardioprotection, as these cells display similar properties to primary cardiomyocytes.
Fretwell, Laurice V, Fretwell, LV
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Matrix‐Activated Aptamer Sensors for Human Serum Analysis
Angewandte Chemie, EarlyView.The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux +8 more
wiley +2 more sources
Frontiers in Pharmacology, 2016 Both adenosine A1 receptor and cGMP inhibit synaptic transmission at the hippocampus and recently it was found that A1 receptor increased cGMP levels in hippocampus, but the role of cGMP on A1 receptor-mediated inhibition of synaptic transmission remains
Isa ePinto +5 more
doaj +1 more source