Results 81 to 90 of about 119,693 (290)

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Adenosine signaling in airways: Toward a promising antiasthmatic approach [PDF]

, 2013
Adenosine participates to asthma physiopathology by signaling through more than just one receptor subtype. Defining the role of each receptor is complicated by evidence that often results obtained on rodents do not coincide with human studies, but what ...
CICALA, CARLA, IALENTI, ARMANDO
core   +1 more source

Alpha‐Lipoic Acid Alleviates Isoflurane‐Induced Cognitive Dysfunction in Juvenile Mice by Activating Peroxisome Proliferator Activated Receptor Gamma Coactivator ‐1 Alpha

Food Frontiers, EarlyView.
Alpha‐lipoic acid (ALA) plays a significant role in alleviating isoflurane‐induced cognitive dysfunction in juvenile mice by activating PGC‐1α, which improves mitochondrial function and energy metabolism in astrocytes. As a potent antioxidant, ALA is commonly found in foods like spinach, broccoli, and yeast, and its supplementation may offer ...
Xingkai Zhao, Donglu Wang, Shuai Li, Xueting Zhang, Zhenlei Zhou   +4 more
wiley   +1 more source

Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?

Journal of Pharmacological Sciences, 2006
.: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with
Sonja Vučković, Maja Tomić, Radica Stepanović-Petrović, Nenad Ugrešić, Milica Prostran, Bogdan Bošković   +5 more
doaj  

A1 adenosine receptor evoked Ca2+ signals in astrocytes

Current Directions in Biomedical Engineering
In addition to neurons, glial cells make up the nervous system. These glial cells are divided into macroglial cells - including astrocytes - and microglial cells.
Kienleitner Filip, Lenk Kerstin
doaj   +1 more source

Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine

Glia, EarlyView.
Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani, Tommaso Dalla‐Tor, Tommaso Garavaldi, Francisca Julio‐Kalajzić, Doriane Gisquet, Paula Gomez‐Sotres, Astrid Cannich, Giuditta Gambino, Filippo Drago, Roman Serrat, Imane Hurel, Francis Chaouloff, Sandrine Pouvreau, Luigi Bellocchio, Giovanni Marsicano, Ana Covelo   +15 more
wiley   +1 more source

Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

Journal of Pharmacological Sciences, 2004
Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone),
Takuya Maemoto, Miho Tada, Takuma Mihara, Noriko Ueyama, Hideaki Matsuoka, Katsuya Harada, Takayuki Yamaji, Kiyoharu Shirakawa, Satoru Kuroda, Atsushi Akahane, Akinori Iwashita, Nobuya Matsuoka, Seitaro Mutoh   +12 more
doaj  

Reducing Extracellular Ca2+ Induces Adenosine Release via Equilibrative Nucleoside Transporters to Provide Negative Feedback Control of Activity in the Hippocampus

Frontiers in Neural Circuits, 2017
Neural circuit activity increases the release of the purine neuromodulator adenosine into the extracellular space leading to A1 receptor activation and negative feedback via membrane hyperpolarization and inhibition of transmitter release.
Rebecca Diez, Magnus J. E. Richardson, Mark J. Wall   +2 more
doaj   +1 more source

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers

Journal of Neuroscience, 2006
The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the present study, we demonstrate that heteromerization of adenosine A1 receptors (A1Rs) and A2A receptors (A2ARs) allows adenosine to exert a fine-tuning ...
F. Ciruela, V. Casadó, R. Rodrigues, R. Luján, J. Burgueño, Meritxell Canals, J. Borycz, N. Rebola, S. Goldberg, J. Mallol, Antonio Cortés, E. Canela, J. López-Giménez, G. Milligan, C. Lluis, R. Cunha, S. Ferré, R. Franco   +17 more
semanticscholar   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source