Results 271 to 280 of about 271,431 (312)
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Arresting angiotensin type 1 receptors
Trends in Endocrinology and Metabolism, 2003The type 1 angiotensin (AT(1)) receptor mediates the homeostatic and pathological actions of the peptide hormone, angiotensin II. With regard to the processes that activate and deactivate seven-transmembrane-spanning, G-protein-coupled receptors (GPCRs), AT(1) receptors are among the most widely studied, serving as prototypes for GPCRs that bind and ...
Thomas, Walter G., Qian, Hongwei
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Type 1 angiotensin II receptors of adrenal tumors
Steroids, 1995The present study was designed to clarify the transcriptional regulation of the human type 1 angiotensin II receptor (AT1) gene and its pathophysiological roles in steroidogenesis by adrenal tumors. A cDNA encoding type 1 angiotensin II receptor (AT1) was isolated from a human liver cDNA library encoding a protein of 359 amino acids with seven ...
H, Nawata +8 more
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Angiotensin (1???7) is an antagonist at the type 1 angiotensin II receptor
Journal of Hypertension, 1994The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats.In rabbit isolated endothelium intact aortic rings Ang(1-7) caused a concentration-related rightward displacement of the Ang II ...
J M, Mahon +3 more
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Angiotensin type-1 receptor blockers in heart failure
Progress in Cardiovascular Diseases, 2002Chronic heart failure is a common condition with a poor prognosis, usually associated with poor exercise tolerance and debilitating symptoms despite optimal modern therapy. Standard therapy includes diuretics, digoxin, angiotensin-converting enzyme inhibitors (ACEIs) and beta-blockers.
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Valsartan: a novel angiotensin Type 1 receptor antagonist
Expert Opinion on Pharmacotherapy, 2000Valsartan is a highly selective, orally available antagonist of the angiotensin Type 1 (AT1) receptor. It is indicated for treatment of mild to moderate essential hypertension. Experimental studies have confirmed the abolition or attenuation of angiotensin II (AII)-related effects, such as vasoconstriction, cell growth promotion and aldosterone release.
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Regulation of Vascular Type 1 Angiotensin Receptors by Cytokines
Hypertension, 1997AbstractAlthough various cytokines are known to be expressed in atherosclerotic lesions, it is not known how these cytokines affect receptors for the peptide hormone angiotensin II (Ang II). We therefore examined the effects of interleukin-1α (220 U/mL [10 ng/mL]), tumor necrosis factor-α (280 U/mL [100 ng/mL]), and interferon gamma (100 U/mL) on Ang ...
H, Sasamura +5 more
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[Angiotensin-2 type 1 receptors (AT1R) and cancers].
Nephrologie & therapeutique, 2013Recently, several meta-analysis suggested an increased risk of cancers linked to the use of antagonists of angiotensin-2 receptors or inhibitors of angiotensinogen converting enzyme. The results of epidemiological studies are conflicting. Meta-analysis as well as retrospective studies are not reliable and biased, since they have never been designed to ...
Dolley-Hitze, Thibault +8 more
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Biased Agonism of the Angiotensin II Type 1 Receptor
Mini-Reviews in Medicinal Chemistry, 2012G protein-coupled receptors (GPCRs) can be activated by multiple ligands and exhibit the capacity to couple to numerous intracellular signal transduction pathways. This property allows GPCRs to be modulated by biased agonists that selectively activate specific subsets of GPCR-regulated cellular signaling proteins.
C M, Godin, S S G, Ferguson
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