Results 91 to 100 of about 1,265,475 (213)

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

METHODS FOR RECOMBINANT EXPRESSION AND FUNCTIONAL CHARACTERIZATION OF HUMAN CANNABINOID RECEPTOR CB2

Computational and Structural Biotechnology Journal, 2013
Cannabinoid receptor CB2 is a seven transmembrane-domain integral membrane protein that belongs to a large superfamily of G protein-coupled receptors (GPCR).
Alexei A. Yeliseev
doaj   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Storr, Martin, Huber, Erasmus, Azad, Shahnaz C., Schelling, Gustav, Vogeser, Michael, Hauer, Daniela   +5 more
core   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Expression of cannabinoid receptors CB1, CB2 and GPR18 in adenomyotic lesions

Journal of Endometriosis and Uterine Disorders
The aim of this study was to assess if cannabinoid receptors CB1, CB2 and GPR18 are expressed in adenomyotic tissues. For this purpose, gene expression analysis was carried on RNA extracted from the nodular adenomyotic lesions of patients affected by ...
Matteo Prisinzano, Maryam Raeispour, Margherita Rossi, Isabelle Seidita, Silvia Vannuccini, Massimiliano Fambrini, Eleonora Nardi, Francesca Castiglione, Felice Petraglia, Caterina Bernacchioni, Chiara Donati   +10 more
doaj   +1 more source

Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors

Cellular Physiology and Biochemistry, 2017
Background/Aims: Remote ischemic preconditioning (RIPC) has protective effects on spinal cord ischemia reperfusion (I/R) injury, but the potential mechanisms remain unclear. In our study, the effects and underlying mechanisms of RIPC on blood-spinal cord
Na Jing, Bo Fang, Zhi-Lin Wang, Hong Ma
doaj   +1 more source

Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor

Pharmaceuticals, 2014
Cannabinoid receptor subtype 2 (CB2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and ...
Linjing Mu, Roger Slavik, Adrienne Müller, Kasim Popaj, Stjepko Čermak, Markus Weber, Roger Schibli, Stefanie D. Krämer, Simon M. Ametamey   +8 more
doaj   +1 more source

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

, 2009
Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB1 cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and ...
Azcoitia Elías, Íñigo, Julien, Boris, Romero, Julián, Guzmán Pastor, Manuel, Galve Roperh, Ismael, Palazuelos Diego, Javier, Fernández Ruiz, José Javier, Pazos, Ruth, Sagredo Ezquioga, Onintza, Benito, Cristina, Aguado Sánchez, Tania, Carrasco, Carolina, Resel, Eva   +12 more
core   +1 more source

CB2 cannabinoid receptor as potential target against Alzheimer’s disease

Frontiers in Neuroscience, 2016
The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions.
Ester eAso, Isidro eFerrer
doaj   +1 more source