Results 101 to 110 of about 1,265,475 (213)

Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent

Breast Cancer: Targets and Therapy, 2016
Katherine E Hanlon,1,2 Alysia N Lozano-Ondoua,1 Puja J Umaretiya,1 Ashley M Symons-Liguori,1 Anupama Chandramouli,1 Jamie K Moy,1 William K Kwass,1 Patrick W Mantyh,1 Mark A Nelson,3 Todd W Vanderah,11Department of Pharmacology, University of Arizona ...
Hanlon KE, Lozano-Ondoua AN, Umaretiya PJ, Symons-Liguori AM, Chandramouli A, Moy JK, Kwass WK, Mantyh PW, Nelson MA, Vanderah TW   +9 more
doaj  

The Cannabinoid Pharmacology of Bone Healing: Developments in Fusion Medicine

Biomedicines
Background/Objectives: Cannabinoid use is rising among patients undergoing spinal fusion, yet its influence on bone healing is poorly defined. The endocannabinoid system (ECS)—through cannabinoid receptors 1 (CB1) and 2 (CB2)—modulates skeletal ...
Gabriel Urreola, Michael Le, Alan Harris, Jose A. Castillo, Augustine M. Saiz, Hania Shahzad, Allan R. Martin, Kee D. Kim, Safdar Khan, Richard Price   +9 more
doaj   +1 more source

Cardio-renal effects of chronic administration with CB2 agonist AM1241 and CB2 antagonist AM630 in rats with diet induced obesity

, 2013
It is widely recognised that obesity elicits a number of comorbidities including heart and kidney disease. The progression of these diseases is frequently exacerbated by other clinical factors associated with obesity such as hypertension and metabolic ...
Mathai, Michael L., McAinch, Andrew J., Simcocks, Anna, O'Keefe, Lannie, Hryciw, Deanne H., Jenkin, Kayte A. (R19563)   +5 more
core  

The CB2 cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of animal model of multiple sclerosis

, 2008
Cannabinoids are potential agents for the development of therapeutic strategies against multiple sclerosis. Here we analyzed the role of the peripheral CB2 cannabinoid receptor in the control of myeloid progenitor cell trafficking toward the inflamed ...
Mechoulam, Raphael, Davoust, Natalie, Hatterer, Eric, Benito Villalvilla, Cristina, Julien, Boris, Romero, Julián, Guzmán Pastor, Manuel, Galve Roperh, Ismael, Nataf, Serge, Aguado Sánchez, Tania, Silva, Augusto, Palazuelos Diego, Javier   +11 more
core   +1 more source

Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections [PDF]

, 2012
Background: After focal neuronal injury the endocannabinioid system becomes activated and protects or harms neurons depending on cannabinoid derivates and receptor subtypes.
Geisslinger, Gerd, Gerd Geisslinger, Ziebell Simone, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Natsuo Ueda, Ueda Natsuo, Dehghani Faramarz, Faramarz Dehghani (109822), Hobusch Constance, Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Koch Marco, Geisslinger Gerd, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Natsuo Ueda (176896), Constance Hobusch, Kallendrusch Sonja, Ehrlich Angela, Kallendrusch, Sonja, Ueda, Natsuo, Marco Koch, Angela Ehrlich (109799)   +31 more
core   +2 more sources

New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors

, 2006
Since the discovery that Delta 9-tetrahydrocannabinol and related cannabinoids from Cannabis sativa L. act on specific physiological receptors in the human body and the subsequent elucidation of the mammalian endogenous cannabinoid system, no other ...
Gertsch, Jürg, Raduner, Stefan, Altmann, Karl-Heinz   +2 more
core   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio
Intracellular Ca2+ regulates insulin secretion from pancreatic β‐cells and is influenced by cannabinoid signaling. However, the hydrophobicity and complex pharmacology of cannabinoid ligands prevent precision receptor targeting, limiting our ...
Alexander E. G. Viray, James A. Frank
doaj   +1 more source

CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

, 2012
The endocannabinoid system is knownto regulate neural progenitor (NP) cell proliferation and neurogenesis. In particular, CB2 cannabinoid receptors have been shown to promote NP proliferation. As CB2 receptors are not expressed in differentiated neurons,
Ortega, Zaira, Díaz-Alonso, Javier, Zaira Ortega, Ismael Galve-Roperh, Guzmán Pastor, Manuel, Galve Roperh, Ismael, Manuel Guzmán, Palazuelos Diego, Javier, Javier Palazuelos, Javier Díaz-Alonso   +9 more
core   +1 more source

Research progress on the cannabinoid type-2 receptor and Parkinson’s disease

Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders.
Xiaoqi Yu, Xiaoqi Yu, Yi Jia, Yuan Dong, Yuan Dong   +4 more
doaj   +1 more source

Cannabinoid CB2 receptor (CNR2) [PDF]

Science-Business eXchange, 2012
openaire   +3 more sources