Results 81 to 90 of about 1,265,475 (213)

N‐Arachidonoyl‐phosphatidylethanolamide phospholipase D activation by muscarinic receptors

The Journal of Physiology, EarlyView.
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Natalia Murataeva, Connor Schmitt, Elyssa Hyman, Jim Wager‐Miller, Irene Matthews, Ruyi Cai, Shangxuan Cai, Yulong Li, Ken Mackie, Alex Straiker   +9 more
wiley   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +2 more sources

Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis.

PLoS ONE, 2013
Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55).
Sofia Sisay, Gareth Pryce, Samuel J Jackson, Carolyn Tanner, Ruth A Ross, Gregory J Michael, David L Selwood, Gavin Giovannoni, David Baker   +8 more
doaj   +1 more source

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain

Molecules, 2019
Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs.
Esraa Aly, Maitham A. Khajah, Willias Masocha   +2 more
doaj   +1 more source

Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol

Arhiv za Higijenu Rada i Toksikologiju, 2020
Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because
Černe Katarina
doaj   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Cannabinoid CB2 Receptor Ligands Datasets

, 2019
Datasets used in the work titled: "A Multiple Classifier System Identifies Novel Cannabinoid CB2 Receptor Ligands" CB2 Dataset contains the dataset used by D2-MCS platform to generate Multi-Classifier Systems.
Burggraaff, Lindsey, Burggraaff, Lindsey (6682622), Ruano-Ordas, David (6682619), van Westen, Gerard J. P. (6682625), van Westen, Gerard J. P., Ruano-Ordas, David   +5 more
core   +1 more source

Cannabinoid Receptor CB2 Is Involved in Tetrahydrocannabinol-Induced Anti-Inflammation against Lipopolysaccharide in MG-63 Cells

Mediators of Inflammation, 2015
Cannabinoid Δ9-tetrahydrocannabinol (THC) is effective in treating osteoarthritis (OA), and the mechanism, however, is still elusive. Activation of cannabinoid receptor CB2 reduces inflammation; whether the activation CB2 is involved in THC-induced ...
Lei Yang, Fei-Fei Li, Yu-Chen Han, Bin Jia, Yin Ding   +4 more
doaj   +1 more source

CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

Pain, 2002
The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivity and anti-inflammatory activity was 5 g/kg-1 i.p. (in the carrageenan model).
Clayton, N, Marshall, F, Bountra, C, O'Shaughnessy, C   +3 more
openaire   +3 more sources

Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS [PDF]

Current Neuropharmacology, 2011
Cannabinoids are the constituents of the marijuana plant (Cannabis sativa). There are numerous cannabinoids and other natural compounds that have been reported in the cannabis plant. The recent progress in marijuana-cannabinoid research include the discovery of an endocannabinoid system with specific genes coding for cannabinoid receptors (CBRs) that ...
openaire   +2 more sources