Results 31 to 40 of about 11,404 (192)
Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid
British Journal of Pharmacology, 2013 Background and PurposeAlthough cannabinoid CB2 receptor ligands have been widely characterized in recombinant systems in vitro, little pharmacological characterization has been performed in tissues natively expressing CB2 receptors. The aim of this study was to compare the pharmacology of CB2 receptor ligands in tissue natively expressing CB2 receptors
Pietro, Marini +4 more
openaire +2 more sources
Cannabinoids: A New Group of Agonists of PPARs
PPAR Research, 2007 Cannabinoids have been used medicinally and recreationally for thousands of years and their effects were proposed to occur mainly via activation of the G-protein-coupled receptor CB1/CB2 (cannabinoid receptor 1/2).
Yan Sun, Andy Bennett
doaj +1 more source
Journal of Pharmacological Sciences, 2019 Neuropathic pain sometimes occurs during chemotherapy with paclitaxel or HIV/AIDS antiretroviral therapy with nucleoside reverse transcriptase inhibitors (NRTIs).
Willias Masocha, Amal Thomas
doaj +1 more source
Cannabinoid receptors distribution in mouse cortical plasma membrane compartments
Molecular Brain, 2021 The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons ...
Hajar Miranzadeh Mahabadi +3 more
doaj +1 more source
Cannabinoid Receptor CB2 Structure and CB2/Gi Signaling Mechanisms
The FASEB Journal, 2019 Cannabinoid receptor subtype 2 (CB2) is a class‐A family G protein‐coupled receptor (GPCR), located primarily in immune‐associated tissues and implicated in several immune and inflammatory diseases. Drugs targeting CB2 are predicted to be effective treatment alternatives for chronic neuropain and neuroinflammatory autoimmune ...
Changrui Xing +2 more
openaire +1 more source
C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor [PDF]
Bioorganic & Medicinal Chemistry Letters, 2012 A series of tricyclic cannabinoids incorporating a heteroaroyl group at C3 were prepared as probes to explore the binding site(s) of the CB1 and CB2 receptors. This relatively unexplored structural motif is shown to be CB2 selective with K(i) values at low nanomolar concentrations when the heteroaromatic group is 3-benzothiophenyl (41) or 3-indolyl (50)
Darryl D, Dixon +7 more
openaire +2 more sources
Pharmacology Research & Perspectives, 2023 The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern.
Monica Patel +4 more
doaj +1 more source
Molecules, 2022 Zebrafish (ZF; Danio rerio) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate (4F-MDMB-BINACA) in ZF larvae after ...
Yu Mi Park +5 more
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Sentience in cephalopod molluscs: an updated assessment
Biological Reviews, EarlyView.ABSTRACT This article evaluates the evidence for sentience – the capacity to have feelings – in cephalopod molluscs: octopus, cuttlefish, squid, and nautilus. Our framework includes eight criteria, covering both whether the animal's nervous system could support sentience and whether their behaviour indicates sentience.
Alexandra K. Schnell +4 more
wiley +1 more source
Protocol for crystal structure determination of the antagonist-bound human cannabinoid receptor CB2
STAR Protocols, 2021 Summary: Human cannabinoid receptor CB2 plays an important role in the immune system and is an attractive therapeutic target for pain and for inflammatory and neurodegenerative diseases.
Ling Shen +5 more
doaj +1 more source