Results 91 to 100 of about 21,687 (230)

Fluorescence polarization screening for allosteric small molecule ligands of the Cholecystokinin Receptor

, 2011
The success in screening for drug candidates is highly dependent on the power of the strategy implemented. In this work, we report and characterize a novel fluorescent benzodiazepine antagonist of the type 1 cholecystokinin receptor (3-(3-(7-fluoro-1-(2 ...
Kaleeckal G. Harikumar, Miller, LJ, Harikumar, KG, Erin E. Cawston, Laurence J. Miller, Cawston, Erin   +5 more
core   +1 more source

Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function

Journal of Lipid Research, 2006
C57L mice are susceptible and AKR mice are resistant to gallstone formation. We studied in male mice of both strains gallbladder histopathology, cholecystokinin-induced emptying, and concentrating function at 0, 14, 28, and 56 days on a lithogenic diet ...
Karel J. van Erpecum, David Q-H. Wang, Antonio Moschetta, Domenico Ferri, Maria Svelto, Piero Portincasa, Jan-Jaap Hendrickx, Marguérite Schipper, Giuseppe Calamita   +8 more
doaj   +1 more source

Development of a new radioligand for cholecystokinin receptor subtype 2 scintigraphy: from molecular modeling to in vivo evaluation.

, 2010
International audienceTo improve the targeting to tumors expressing the cholecystokinin receptor subtype 2 (CCK2R) with limited kidney uptake, we synthesized a novel cholecystokinin C-terminal tetrapeptide (CCK4)-based derivative conjugated to an ...
Dorbes, Sandra, Silvente-Poirot, Sandrine, Delord, Jean Pierre, Poirot, Marc, E., Courbon, Frédéric, Brillouet, Séverine, Picard, Claude, Benoist, Eric, Mestre-Voegtlé, Béatrice   +8 more
core   +1 more source

Cholecystokinin Receptor-Targeted Polyplex Nanoparticle Inhibits Growth and Metastasis of Pancreatic Cancer

Cellular and Molecular Gastroenterology and Hepatology, 2018
Pancreatic ductal adenocarcinoma (PDAC) remains the most aggressive malignancy with the lowest 5-year survival rate of all cancers in part owing to the lack of tumor-specific therapy and the rapid metastatic nature of this cancer.
Julian Burks, Sandeep Nadella, Abdullah Mahmud, Charoen Mankongpaisarnrung, Juan Wang, Jong-In Hahm, Robin D. Tucker, Narayan Shivapurkar, Stephan T. Stern, Jill P. Smith   +9 more
doaj   +1 more source

Upregulation of CCK3R leading to the suppression of chronic seizures

Translational Psychiatry
Epilepsy is a chronic neurological disorder characterized by recurrent seizures that affect millions globally. Despite the availability of various antiepileptic drugs, 30–40% of patients remain drug-resistant and continue to experience seizures.
Ling He, Liyang Zhang, Yujie Yang, Junming Ren, Zhoujian Xiao, Yihao Li, Yuandi Zhao, Feixu Jiang, Dingxuan Zeng, Xin Yan, Yanyan Sun, Jufang He   +11 more
doaj   +1 more source

Comparative analysis of the hypothalamus transcriptome of laying ducks with different residual feeding intake

Poultry Science
: Feed costs account for approximately 60 to 70% of the cost of poultry farming, and feed utilization is closely related to the profitability of the poultry industry.
Rongbing Guo, Tao Zeng, Dandan Wang, Ayong Zhao, Shiheng Zhou, Zhizhou Huang, Yuguang Chang, Hanxue Sun, Tiantian Gu, Li Chen, Yong Tian, Wenwu Xu, Lizhi Lu   +12 more
doaj   +1 more source

Effect of a Single Nucleotide Polymorphism in the Cholecystokinin Type A Receptor Gene on Growth Traits of the Miyazaki Jitokko Chicken

The Journal of Poultry Science, 2019
The Miyazaki Jitokko chicken, native to the Miyazaki Prefecture in southern Kyushu Island, Japan, is the product of a three-way cross involving the Jitokko, White Plymouth Rock, and Kyushu Rhode breeds. In the present study, associations between a single
Shojiroh Horinouchi, Hiromi Nakayama, Hideaki Takahashi   +2 more
doaj   +1 more source

Cyclic nucleotide antagonists of cholecystokinin: structural requirements for interaction with the cholecystokinin receptor

, 1982
Previously, we have found that, in pancreatic acini, butyryl derivatives of cGMP antagonize the action of cholecystokinin by inhibiting binding of the peptide to its membrane receptors.
R. T. Jensen, N. Barlas, M. C. Beinfeld, J. D. Gardner   +3 more
core   +1 more source

Bovine gallbladder muscularis: source of a myogenic receptor for cholecystokinin

, 1988
Despite being a classic target for the gastrointestinal peptide hormone, cholecystokinin (CCK), the gallbladder CCK receptor is not well characterized.
B. Schjoldager, M. J. Shaw, P. F. Schmalz, J. Szurszewski, S. P. Powers, L. J. Miller   +5 more
core   +1 more source

Cholecystokinin receptor type A are involved in the circadian rhythm of the mouse retina

Heliyon
The retina is the only organ projecting external light to the suprachiasmatic nucleus. Cholecystokinin receptor type A (Cckar/Cckar) is one of the essential factors for light reception in retinal cells. As there was a lack of literature on the matter, we
Yusuke Yamakawa, Yuya Tsurudome, Masaki Tamada, Yuki Tsuchimochi, Yuya Umeda, Yuya Yoshida, Daisuke Kobayashi, Takehiro Kawashiri, Toshio Kubota, Naoya Matsunaga, Takao Shimazoe   +10 more
doaj   +1 more source